A novel tool to eradicate an ancient scourge: the novel oral polio vaccine type 2 story
AS Bandyopadhyay, S Zipursky - The Lancet Infectious Diseases, 2023 - thelancet.com
The recent detection of vaccine-derived poliovirus (VDPV) in London (UK) and a case of
paralytic polio in New York (USA) have highlighted how the scourge of poliomyelitis has not …
paralytic polio in New York (USA) have highlighted how the scourge of poliomyelitis has not …
Controlled human infection models to accelerate vaccine development
RKM Choy, AL Bourgeois… - Clinical Microbiology …, 2022 - Am Soc Microbiol
The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
The safety and immunogenicity of two novel live attenuated monovalent (serotype 2) oral poliovirus vaccines in healthy adults: a double-blind, single-centre phase 1 …
P Van Damme, I De Coster, AS Bandyopadhyay… - The Lancet, 2019 - thelancet.com
Background Use of oral live-attenuated polio vaccines (OPV), and injected inactivated polio
vaccines (IPV) has almost achieved global eradication of wild polio viruses. To address the …
vaccines (IPV) has almost achieved global eradication of wild polio viruses. To address the …
Evaluation of the safety, immunogenicity, and faecal shedding of novel oral polio vaccine type 2 in healthy newborn infants in Bangladesh: a randomised, controlled …
K Zaman, AS Bandyopadhyay, M Hoque, C Gast… - The Lancet, 2023 - thelancet.com
Background Type 2 circulating vaccine-derived polioviruses (cVDPV2) from Sabin oral
poliovirus vaccines (OPVs) are the leading cause of poliomyelitis. A novel type 2 OPV …
poliovirus vaccines (OPVs) are the leading cause of poliomyelitis. A novel type 2 OPV …
Assessment of serological responses following vaccination campaigns with type 2 novel oral polio vaccine: a population-based study in Tajikistan in 2021
A Mirzoev, GR Macklin, Y Zhang, BA Mainou… - The Lancet Global …, 2022 - thelancet.com
Background Novel oral poliovirus vaccine type 2 (nOPV2) was used to control an outbreak
of type 2 circulating vaccine derived poliovirus (cVDPV2) in Tajikistan, in 2021. We …
of type 2 circulating vaccine derived poliovirus (cVDPV2) in Tajikistan, in 2021. We …
[HTML][HTML] Mucosal immunity to poliovirus
RI Connor, EB Brickley, WF Wieland-Alter… - Mucosal …, 2022 - Elsevier
A cornerstone of the global initiative to eradicate polio is the widespread use of live and
inactivated poliovirus vaccines in extensive public health campaigns designed to prevent …
inactivated poliovirus vaccines in extensive public health campaigns designed to prevent …
Life-threatening infections due to live-attenuated vaccines: early manifestations of inborn errors of immunity
L Pöyhönen, J Bustamante, JL Casanova… - Journal of clinical …, 2019 - Springer
Live-attenuated vaccines (LAVs) can protect humans against 12 viral and three bacterial
diseases. By definition, any clinical infection caused by a LAV that is sufficiently severe to …
diseases. By definition, any clinical infection caused by a LAV that is sufficiently severe to …
Safety and immunogenicity of inactivated poliovirus vaccine schedules for the post-eradication era: a randomised open-label, multicentre, phase 3, non-inferiority trial
AS Bandyopadhyay, C Gast, L Rivera… - The Lancet Infectious …, 2021 - thelancet.com
Background Following the global eradication of wild poliovirus, countries using live
attenuated oral poliovirus vaccines will transition to exclusive use of inactivated poliovirus …
attenuated oral poliovirus vaccines will transition to exclusive use of inactivated poliovirus …
Vaccine schedules and the effect on humoral and intestinal immunity against poliovirus: a systematic review and network meta-analysis
GR Macklin, NC Grassly, RW Sutter, O Mach… - The Lancet Infectious …, 2019 - thelancet.com
Background The eradication of wild and vaccine-derived poliovirus requires the global
withdrawal of oral poliovirus vaccines (OPVs) and replacement with inactivated poliovirus …
withdrawal of oral poliovirus vaccines (OPVs) and replacement with inactivated poliovirus …
The role of genetic sequencing and analysis in the polio eradication programme
D Jorgensen, M Pons-Salort, AG Shaw… - Virus …, 2020 - academic.oup.com
Genetic sequencing of polioviruses detected through clinical and environmental
surveillance is used to confirm detection, identify their likely origin, track geographic patterns …
surveillance is used to confirm detection, identify their likely origin, track geographic patterns …