Calcium (Ca2+) is an essential signaling molecule that controls a wide range of biological
functions. In the immune system, calcium signals play a central role in a variety of cellular …

Germinal centers (GCs) were described more than 125 years ago as compartments within
secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that …

Immune imbalance of T lymphocyte subsets is a hallmark of psoriasis, but the molecular
mechanisms underlying this aspect of psoriasis pathology are poorly understood. Here, we …

Abstract PD-1, a 55 kDa transmembrane protein containing an immunoreceptor tyrosine-
based inhibitory motif, is induced in lymphocytes and monocytic cells following activation …

Inflammation is a complex set of interactions among soluble factors and cells that can arise
in any tissue in response to traumatic, infectious, post-ischaemic, toxic or autoimmune injury …

Targeted therapy with imatinib and other selective tyrosine kinase inhibitors has transformed
the treatment of chronic myeloid leukemia. Unlike chronic myeloid leukemia, chronic …

Discrimination of self from non-self is fundamental to a wide range of immunological
processes. During pregnancy, the mother does not recognize the placenta as …

Calcium signals in cells of the immune system participate in the regulation of cell
differentiation, gene transcription and effector functions. An increase in intracellular levels of …

Tissue wounding induces the rapid recruitment of leukocytes. Wounds and tumours—a type
of 'unhealed wound'—generate hydrogen peroxide (H2O2) through an NADPH oxidase …

The physiology of B cells is intimately connected with the function of their B‐cell receptor
(BCR). B‐cell lymphomas frequently (dys) regulate BCR signalling and thus take advantage …