The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have
been sampled to date in the form of expressed sequence tags. An international consortium …

Recent spectacular advances in the technologies and strategies for DNA sequencing have
profoundly accelerated the detailed analysis of genomes from myriad organisms. The past …

Hereditary haemochromatosis (HH), which affects some 1 in 400 and has an estimated
carrier frequency of 1 in 10 individuals of Northern European descent, results in multi–organ …

THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by
abnormally high blood glucose resulting from a relative deficiency of insulin1. It affects about …

Telomerase, the ribonucleoprotein enzyme that elongates telomeres, is repressed in normal
human somatic cells but is reactivated during tumor progression. We report the cloning of a …

We have developed epifluorescence filter sets and computer software for the detection and
discrimination of 27 different DNA probes hybridized simultaneously. For karyotype analysis …

THE great increase in successful linkage studies in a number of higher eukaryotes during
recent years has essentially resulted from major improvements in reference genetic linkage …

DNA in amounts representative of hundreds of eukaryotic genomes was extended on
silanized surfaces by dynamic molecular combing. The precise measurement of hybridized …

Marginal zone cell lymphomas of the mucosa-associated lymphoid tissue (MALT) are the
most common subtype of lymphoma arising at extranodal sites. The t (11; 18)(q21; q21) …

Genes associated with inherited retinal degeneration have been found to encode proteins
required for phototransduction, metabolism, or structural support of photoreceptors. Here we …