An extraordinary series of discoveries about chronic myeloid leukemia (CML) has made this
disease a model of the way in which bench and bedside research can unite and culminate …

Chronic myeloid leukemia (CML) was the first human malignancy to be associated with a
specific genetic lesion, the Philadelphia chromosome, harboring the BCR-ABL oncogene …

Background: Fusion transcripts are formed by either fusion genes (DNA level) or trans-
splicing events (RNA level). They have been recognized as a promising tool for diagnosing …

Background Outcomes of chronic myeloid leukemia (CML) has been improved dramatically
in the past two decades, but survival levels of CML patients varied in regions …

Treatments for chronic myeloid leukemia (CML) represent a success story in molecular
medicine. The development of imatinib, a tyrosine kinase inhibitor (TKI) targeted against the …

Chromosomal rearrangements involving the ABL1 gene, leading to a BCR‐ABL1 fusion
gene, have been mainly associated with chronic myeloid leukemia and B‐cell acute …

The clinical significance of gene fusions detected by DNA-based next generation
sequencing remains unclear as resistance mechanisms to EGFR tyrosine kinase inhibitors …

Carcinogenesis and cancer therapy are two sides of the same coin, such that the same
cytotoxic agent can cause cancer and be used to treat cancer. This review links …

Acute lymphoblastic leukemia (ALL) is a heterogeneous disorder, with the greatest
prevalence in children, but it also affects adults, and has an increasing incidence with age …

BCR–ABL fusion proteins show increased signaling through their ABL tyrosine kinase
domain, which can be blocked by specific inhibitors, thereby providing effective treatment …