In the last decade, basic cancer research has produced remarkable advances in our
understanding of cancer biology and cancer genetics. Among the most important of these …

The discovery of a novel proteolytic network in the cytosol of metazoan cells comes as a
surprise to a field that previously considered intracellular proteolysis to mainly be a …

In multicellular organisms, mutations in somatic cells affecting critical genes that regulate
cell proliferation and survival cause fatal cancers. Repair of the damage is one obvious …

Growth factors signaling through the phosphoinositide 3-kinase/Akt pathway promote cell
survival. The mechanism by which the serine/threonine kinase Akt prevents cell death …

The observation that the nematode cell death effector gene product Ced-3 is homologous to
human interleukin-1β-converting enzyme (caspase-1) has led to the discovery of at least …

Caspases are cysteine proteases that mediate apoptosis by proteolysis of specific
substrates. Although many caspase substrates have been identified, for most substrates the …

Much recent research on c-Myc has focused on how it drives apoptosis. c-Myc is widely
known as a crucial regulator of cell proliferation in normal and neoplastic cells, but until …

Caspases are proteases at the heart of networks that govern apoptosis and inflammation.
The past decade has seen huge leaps in understanding the biology and chemistry of the …

Recent genome sequencing studies have identified several classes of complex genomic
rearrangements that appear to be derived from a single catastrophic event. These …

Inactivation of p53-dependent apoptosis promotes oncogenic transformation, tumor
development, and resistance to many cytotoxic anticancer agents. p53 can transcriptionally …