With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

Hairpins represent the dominant secondary structure element in RNA. Certain sequences
are found with exceptional frequency in many RNAs and are characterized by exceptionally …

This communication presents results from molecular dynamics (MD) simulations with
AMBER 4.11 and the Cornell et al? force field of three different, fully solvated, fully charged …

The reactivity of an RNA ribose hydroxyl is shown to be exquisitely sensitive to local
nucleotide flexibility because a conformationally constrained adjacent 3 '-phosphodiester …

In many eukaryotes, expression of nuclear-encoded mRNA can be strongly inhibited by the
presence of a double-stranded RNA (dsRNA) corresponding to exon sequences in the …

Short peptides that contain the basic region of the HIV-1 Tat protein bind specifically to a
bulged region in TAR RNA. A peptide that contained nine arginines (R9) also bound …

A remaining challenge for the human genome project involves the identification and
annotation of expressed genes. The public and private sequencing efforts have identified∼ …

The most frequently occurring RNA hairpins in 16 S and 23 S ribosomal RNA contain a
tetranucleotide loop that has a GNRA consensus sequence. The solution structures of the …

Biological catalysis is dominated by enzymes that are made of protein, but several distinct
classes of catalytic RNAs are known to promote chemical transformations that are …

The many important biological functions of RNA range from propagation of genetic
information to catalysis in RNA processing and protein synthesis [l]. This diverse array of …