Biological activity requires a solvent that can provide a suitable environment, which satisfies
the twin need for stability and the ability to change. Among all the solvents water plays the …

Insulin is a peptide hormone known for chiefly regulating glucose level in blood among
several other metabolic processes. Insulin remains the most effective drug for treating …

Before the discovery of insulin, a diabetes patient must face an unavoidable death sentence.
The discovery of insulin is a milestone in medical science, and it is really a revolutionary …

Insulin is a therapeutically relevant molecule with use in treating diabetes patients.
Unfortunately, it undergoes a range of untoward and often unpredictable physical …

Daily injections for basal insulin therapy are far from ideal resulting in hypo/hyperglycemic
episodes associated with fatal complications in type-1 diabetes patients. Here we report a …

Water is essential for the structure, dynamics, energetics, and thus the function of
biomolecules. It is a formidable challenge to elicit, in microscopic detail, the role of the …

Insulin is a principal hormone that is involved in the regulation of glucose levels in the blood.
Oral insulin formulation is a recent development in drug delivery systems. Biocompatible …

Association and dissociation of proteins are important biochemical events. In this Feature
Article, we analyze the available studies of these processes for insulin oligomers in aqueous …

We calculate the rate of dissociation of an insulin dimer into two monomers in water. The
rate of this complex reaction is determined by multiple factors that are elucidated. By …

The year 2021 marked the centenary of the isolation of a therapeutic form of insulin and its
successful use in dogs. This was a landmark moment that subsequently and rapidly led to …