Ovarian cancer is an aggressive disease that is frequently detected at advanced stages and
is initially very responsive to platinum-based chemotherapy. However, the majority of …

Progress in the field of precision medicine has changed the landscape of cancer therapy.
Precision medicine is propelled by technologies that enable molecular profiling, genomic …

Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …

Focal adhesion kinase (FAK) is both a non-receptor tyrosine kinase and an adaptor protein
that primarily regulates adhesion signalling and cell migration, but FAK can also promote …

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and
activated in many cancer types. FAK regulates diverse cellular processes, including growth …

Recurrent cancer that spreads to distant sites is the leading cause of disease-related death
among cancer patients. Cancer cells are likely to disseminate during cancer progression …

Epithelial–mesenchymal transition (EMT) has been implicated in various aspects of tumor
development, including tumor invasion and metastasis, cancer stemness, and therapy …

Focal adhesion kinase (FAK) is a key mediator of tumour progression and metastasis. To
date, clinical trials of FAK inhibitors have reported disappointing efficacy for oncology …

Lung cancer is the most frequent cancer with an aggressive clinical course and high
mortality rates. Most cases are diagnosed at advanced stages when treatment options are …

Highlights•Recent experience with targeted anticancer drugs and immunotherapies suggest
the traditional approach of using the maximal tolerated dose (MTD) is not ideal.•Project …