Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and despite cure
rates exceeding 90% in children, it remains an important cause of morbidity and mortality in …

BCL2 and MCL1 are commonly expressed prosurvival (antiapoptotic) proteins in
hematologic cancers and play important roles in their biology either through dysregulation or …

PURPOSE Targeting the BCL-XL pathway has demonstrated the ability to overcome Janus
kinase inhibitor resistance in preclinical models. This phase II trial investigated the efficacy …

Suppression of apoptosis by expression of antiapoptotic BCL2 family members is a hallmark
of acute myeloblastic leukemia (AML). Induced myeloid leukemia cell differentiation protein …

Acute lymphoblastic leukemia (ALL) is the commonest childhood tumor and remains a
leading cause of cancer death in the young. In the last decade, microarray and sequencing …

Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune
system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well …

Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a recently described
subtype of T-ALL characterized by a unique immunophenotype and genomic profile, as well …

Dysregulation of the B-cell leukemia/lymphoma-2 (BCL-2) family of proteins of the intrinsic
apoptotic pathway is fundamental to the pathophysiology of many hematologic …

Secondary acute myeloid leukemias (AMLs) evolving from an antecedent myeloproliferative
neoplasm (MPN) are characterized by a unique set of cytogenetic and molecular features …

Background Primary analyses of cohort 1a of the REFINE trial showed that addition of
navitoclax to ruxolitinib induced a 35% or greater reduction in spleen volume (SVR 35) and …