The progression of chronic liver diseases (CLD), irrespective of etiology, involves chronic
parenchymal injury, persistent activation of inflammatory response as well as sustained …

Portal hypertension, defined as increased pressure in the portal vein, develops as a
consequence of increased intrahepatic vascular resistance due to the dysregulation of liver …

Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells
representing the interface between blood cells on the one side and hepatocytes and hepatic …

Background & Aims Portal vein thrombosis (PVT) is a relatively frequent event in patients
with cirrhosis. While different risk factors for PVT have been reported, such as decreased …

Cirrhosis is an increasing cause of morbidity and mortality in more developed countries,
being the 14th most common cause of death worldwide but fourth in central Europe …

The liver microcirculatory milieu, mainly composed of liver sinusoidal endothelial cells
(LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in …

Cellular crosstalk is a process through which a message is transmitted within an individual
cell (intracellular crosstalk) or between different cells (intercellular crosstalk). Intercellular …

Portal hypertension is a common complication of chronic liver diseases and is responsible
for most clinical consequences of cirrhosis, which represent the more frequent causes of …

Liver fibrosis is a common feature of sustained liver injury and represents a major public
health problem worldwide. Fibrosis is an active research field and discoveries in the last …

The farnesoid X receptor (FXR) is a nuclear bile acid receptor involved in bile acid
homeostasis, hepatic and intestinal inflammation, liver fibrosis, and cardiovascular disease …