Publisher Summary The availability of monoclonally derived hybridoma antibodies provided
an infinite supply of homogeneous reagents so that laboratories around the world could use …

The conventional model of IgM structure depicts a unique, array of μ, L and J chains, held
together by well-defined disulfide bonds and other interactions. Some, but not all, recent …

The pentameric 71-domain structure of human and mouse immunoglobulin M (IgM) was
investigated by synchrotron X-ray solution scattering and molecular graphics modelling. The …

Complex regional pain syndrome (CRPS) is a painful, disabling, chronic condition whose
etiology remains poorly understood. The recent suggestion that immunological mechanisms …

The cysteine at position 575 of the immunoglobulin μ heavy chain is thought to provide the
only disulfide bonds joining the monomer subunits of mouse polymeric IgM. The importance …

The conventional model of polymeric IgM depicts a unique structure in which the mu heavy
chains and J chain are joined by well defined disulfide bonds involving cysteine residues at …

The approaches to the production of antibodies (Ab) using the techniques of genetic
engineering and expression are reviewed. Genetic engineering facilitates the production of …

Human and mouse IgM can be polymerized as a hexamer in addition to a pentamer. Our
previous work with mouse IgM measured activation of guinea pig complement by highly …

The advent of the nouns' engineer'and'engineering'to the lexicon of molecular biology
caused no serious semantic problems for observers of or participants in the technology of …

Recent observations from Africa have rekindled interest in the role of serum bactericidal
antibodies in protecting against systemic infection with Salmonella enterica serovar …