Structure, function and evolution of three-finger toxins: mini proteins with multiple targets

RM Kini, R Doley - Toxicon, 2010 - Elsevier
Snake venoms are complex mixtures of pharmacologically active peptides and proteins.
These protein toxins belong to a small number of superfamilies of proteins. Three-finger …

Alpha neurotoxins

CM Barber, GK Isbister, WC Hodgson - Toxicon, 2013 - Elsevier
α-Neurotoxins have been isolated from hydrophid, elapid and, more recently, colubrid snake
venoms. Also referred to as postsynaptic neurotoxins or 'curare mimetic'neurotoxins, they …

The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins

K Suryamohan, SP Krishnankutty, J Guillory, M Jevit… - Nature Genetics, 2020 - nature.com
Snakebite envenoming is a serious and neglected tropical disease that kills~ 100,000
people annually. High-quality, genome-enabled comprehensive characterization of toxin …

[图书][B] Handbook of venoms and toxins of reptiles

SP Mackessy - 2016 - taylorfrancis.com
The Handbook of Venoms and Toxins of Reptiles offers" one-stop shopping" to all biologists,
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …

Neurotoxins acting at synaptic sites: A brief review on mechanisms and clinical applications

K Zhou, W Luo, T Liu, Y Ni, Z Qin - Toxins, 2022 - mdpi.com
Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to
receptors that are located in the pre-or post-synaptic membranes, thereby affecting …

Three-finger α-neurotoxins and the nicotinic acetylcholine receptor, forty years on

S Nirthanan, MCE Gwee - Journal of pharmacological sciences, 2004 - jstage.jst.go.jp
The discovery, about forty years ago, of a-bungarotoxin, a three-finger a-neurotoxin from
Bungarus multicinctus venom, enabled the isolation of the nicotinic acetylcholine receptor …

Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activity

J Pawlak, SP Mackessy, BG Fry, M Bhatia… - Journal of Biological …, 2006 - ASBMB
Boiga dendrophila (mangrove catsnake) is a colubrid snake that lives in Southeast Asian
lowland rainforests and mangrove swamps and that preys primarily on birds. We have …

Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: Molecules, mechanisms and medicine

S Nirthanan - Biochemical pharmacology, 2020 - Elsevier
Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …

Irditoxin, a novel covalently linked heterodimeric three‐finger toxin with high taxon‐specific neurotoxicity

J Pawlak, SP Mackessy, NM Sixberry… - The FASEB …, 2009 - Wiley Online Library
A novel heterodimeric three‐finger neurotoxin, irditoxin, was isolated from venom of the
brown treesnake Boiga irregularis (Colubridae). Irditoxin subunit amino acid sequences …

Three-finger snake neurotoxins and Ly6 proteins targeting nicotinic acetylcholine receptors: pharmacological tools and endogenous modulators

VI Tsetlin - Trends in pharmacological sciences, 2015 - cell.com
Snake venom neurotoxins and lymphocyte antigen 6 (Ly6) proteins, most of the latter being
membrane tethered by a glycosylphosphatidylinositol (GPI) anchor, have a variety of …