A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

Increasing evidence suggests that vascular risk factors contribute to neurodegeneration,
cognitive impairment and dementia. While there is considerable overlap between features of …

Oligodendrocyte precursor cells (OPCs) are not merely a transitory progenitor cell type, but
rather a distinct and heterogeneous population of glia with various functions in the …

The tripeptide glutathione is the thiol compound present in the highest concentration in cells
of all organs. Glutathione has many physiological functions including its involvement in the …

Stroke is one of the major causes of disability and mortality worldwide. It is well known that
ischemic stroke can cause gray matter injury. However, stroke also elicits profound white …

A hypothetical model of Alzheimer's disease (AD) as a uniquely human brain disorder
rooted in its exceptional process of myelination is presented. Cortical regions with the most …

Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

Neural stem/progenitor cell (NSPC) proliferation and self‐renewal, as well as insult‐induced
differentiation, decrease markedly with age. The molecular mechanisms responsible for …

Multiple sclerosis is a chronic inflammatory disease of the nervous system in which a T-cell-
mediated inflammatory process is associated with destruction of myelin sheaths. Although …

Aging is associated with significant white matter deterioration and this deterioration is
assumed to be at least partly a consequence of myelin degeneration. The present study …