Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent
kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing …

Melanoma, as a tumor cell derived from melanocyte transformation, has the characteristics
of malignant proliferation, high metastasis, rapid recurrence, and a low survival rate …

Efficient release of promoter-proximally paused RNA Pol II into productive elongation is
essential for gene expression. Recently, we reported that the Integrator complex can bind …

We report a novel multifunctional construct, M1, designed explicitly to target the DNA
damage response in cancer cells. M1 contains both a floxuridine (FUDR) and protein …

Although great progress has been made recently in targeted and immune-based therapies,
additional treatments are needed for most melanoma patients due to acquired …

Vassobia breviflora belongs to the Solanaceae family, possessing biological activity against
tumor cells and is a promising alternative for therapy. The aim of this investigation was to …

Despite advances in treating patients with melanoma, there are still many treatment
challenges to overcome. Studies with snake venom-derived proteins/peptides describe their …

Melanoma is the most dangerous type of skin cancer because of its high invasion and
metastasis ability. Bromodomain-containing protein 4 (BRD4), an acetylation-recognizing …

Abstract Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase. This
enzyme is involved in a plethora of cellular processes, including apoptosis, autophagy, cell …