Over the past 40 years, there has been a strong focus on the development of mathematical
models of angiogenesis, while developmental remodelling has received little such attention …

The vasculature ensures optimal delivery of nutrients and oxygen throughout the body, and
to achieve this function it must continually adapt to varying tissue demands. Newly formed …

Blood-vessel formation generates unique vascular patterns in each individual. The
principles governing the apparent stochasticity of this process remain to be elucidated …

Vascular endothelial (VE)-cadherin in endothelial adherens junctions is an essential
component of the vascular barrier, critical for tissue homeostasis and implicated in diseases …

Cardiovascular morphogenesis involves cell behavior and cell identity changes that are
activated by mechanical forces associated with heart function. Recently, advances in in vivo …

Oxygen heterogeneity in solid tumors is recognized as a limiting factor for therapeutic
efficacy. This heterogeneity arises from the abnormal vascular structure of the tumor, but the …

The vascular system is essential for embryogenesis, healing, and homeostasis. Dysfunction
or deregulated blood vessel function contributes to multiple diseases, including diabetic …

The distribution of red blood cells (RBCs) in the microcirculation determines the oxygen
delivery and solute transport to tissues. This process relies on the partitioning of RBCs at …

Impaired cell polarity is a hallmark of diseased tissue. In the cardiovascular system, laminar
blood flow induces endothelial planar cell polarity, represented by elongated cell shape and …

Cerebral small vessel disease (SVD) is the leading cause of vascular dementia, causes a
quarter of strokes, and worsens stroke outcomes. The disease is characterised by patchy …