T cells undergo positive and negative selection in the thymic cortex and medulla,
respectively. A promiscuous expression of a wide array of self-antigens in the thymus is …

Intrathymic T cell development is a complex process that depends upon continuous
guidance from thymus stromal cell microenvironments. The thymic epithelium within the …

Medullary thymic epithelial cells (mTECs) ectopically express thousands of peripheral-tissue
antigens (PTAs), which drive deletion or phenotypic diversion of self-reactive immature T …

Aire is an important regulator of immunological tolerance, operating in a minute subset of
thymic stromal cells to induce transcripts encoding peptides that guide T cell selection …

Somatic recombination of TCR genes in immature thymocytes results in some cells with
useful TCR specificities, but also many with useless or potentially self-reactive specificities …

Epidermal growth factor receptor (EGFR) is known to be critically involved in tissue
development and homeostasis as well as in the pathogenesis of cancer. Here we showed …

More than 15 years ago, mutations in the autoimmune regulator (AIRE) gene were identified
as the cause of autoimmune polyglandular syndrome type 1 (APS1). It is now clear that this …

In the thymus, diverse populations of thymic epithelial cells (TECs), including cortical and
medullary TECs and their subpopulations, have distinct roles in coordinating the …

The promiscuous expression of tissue-restricted antigens in the thymus, driven in part by
autoimmune regulator (Aire), is critical for the protection of peripheral tissues from …

Autoimmune diseases affect 5% to 8% of the population, and females are more susceptible
to these diseases than males. Here, we analyzed human thymic transcriptome and revealed …