Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer
In tumorous tissues, the absence of vasculature supportive tissues intimates the formation of
leaky vessels and pores (100 nm to 2 μm in diameter) and the poor lymphatic system offers …
leaky vessels and pores (100 nm to 2 μm in diameter) and the poor lymphatic system offers …
Ultrasound-mediated nano drug delivery for treating cancer: Fundamental physics to future directions
The application of biocompatible nanocarriers in medicine has provided several benefits
over conventional treatment methods. However, achieving high treatment efficacy and deep …
over conventional treatment methods. However, achieving high treatment efficacy and deep …
[HTML][HTML] Ultrasound-responsive cavitation nuclei for therapy and drug delivery
K Kooiman, S Roovers, SAG Langeveld… - Ultrasound in medicine …, 2020 - Elsevier
Therapeutic ultrasound strategies that harness the mechanical activity of cavitation nuclei for
beneficial tissue bio-effects are actively under development. The mechanical oscillations of …
beneficial tissue bio-effects are actively under development. The mechanical oscillations of …
[HTML][HTML] Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer
At present, ultrasound radiation is broadly employed in medicine for both diagnostic and
therapeutic purposes at various frequencies and intensities. In this review article, we focus …
therapeutic purposes at various frequencies and intensities. In this review article, we focus …
Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery
Apart from its clinical use in imaging, ultrasound has been thoroughly investigated as a tool
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …
Ultrasound and microbubble mediated therapeutic delivery: Underlying mechanisms and future outlook
Beyond the emerging field of oncological ultrasound molecular imaging, the recent
significant advancements in ultrasound and contrast agent technology have paved the way …
significant advancements in ultrasound and contrast agent technology have paved the way …
[HTML][HTML] Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications
Drug delivery for tumor theranostics involves the extensive use of the enhanced permeability
and retention (EPR) effect. Previously, various types of nanomedicines have been …
and retention (EPR) effect. Previously, various types of nanomedicines have been …
[HTML][HTML] A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer
G Dimcevski, S Kotopoulis, T Bjånes, D Hoem… - Journal of Controlled …, 2016 - Elsevier
Background The primary aim of our study was to evaluate the safety and potential toxicity of
gemcitabine combined with microbubbles under sonication in inoperable pancreatic cancer …
gemcitabine combined with microbubbles under sonication in inoperable pancreatic cancer …
Sonodynamic therapy (SDT): a novel strategy for cancer nanotheranostics
Sonodynamic therapy (SDT) is a promising non-invasive therapeutic modality. Compared to
photo-inspired therapy, SDT provides many opportunities and benefits, including deeper …
photo-inspired therapy, SDT provides many opportunities and benefits, including deeper …
Acoustic behavior of microbubbles and implications for drug delivery
Ultrasound contrast agents are valuable in diagnostic ultrasound imaging, and they
increasingly show potential for drug delivery. This review focuses on the acoustic behavior …
increasingly show potential for drug delivery. This review focuses on the acoustic behavior …