Acute exacerbation of COPD

FW Ko, KP Chan, DS Hui, JR Goddard, JG Shaw… - …, 2016 - Wiley Online Library
The literature of acute exacerbation of chronic obstructive pulmonary disease (COPD) is fast
expanding. This review focuses on several aspects of acute exacerbation of COPD …

Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease

JAE Walters, DJ Tan, CJ White… - Cochrane Database of …, 2018 - cochranelibrary.com
Background Current guidelines recommend that patients with acute exacerbations of
chronic obstructive pulmonary disease (COPD) should be treated with systemic …

Prevalence and risk factors for osteoporosis in individuals with COPD: a systematic review and meta-analysis

YW Chen, AH Ramsook, HO Coxson, J Bon, WD Reid - Chest, 2019 - Elsevier
Background Osteoporosis is prevalent in individuals with COPD. Updated evidence is
required to complement the previous systematic review on this topic to provide best practice …

Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries

GJ Martinez, M Appleton, ZA Kipp… - Physiological …, 2024 - journals.physiology.org
The normal stress response in humans is governed by the hypothalamic-pituitary-adrenal
(HPA) axis through heightened mechanisms during stress, raising blood levels of the …

Burst steroid therapy for acute heart failure: The CORTAHF randomized, open‐label, pilot trial

G Cotter, BA Davison, Y Freund… - European Journal of …, 2024 - Wiley Online Library
Aims Burst steroid therapy, effective in acute respiratory diseases, may benefit patients with
acute heart failure (AHF) in whom inflammatory activation is associated with adverse …

[HTML][HTML] Dual role of microRNA-146a in experimental inflammation in Human Pulmonary Epithelial and Immune cells and expression in Inflammatory Lung diseases

L Gronau, RP Duecker, SP Jerkic, O Eickmeier… - International Journal of …, 2024 - mdpi.com
microRNA (miR)-146a emerges as a promising post-transcriptional regulator in various
inflammatory diseases with different roles for the two isoforms miR-146a-5p and miR-146a …

Therapeutic approaches for chronic obstructive pulmonary disease (COPD) exacerbations

Y Rosenwasser, I Berger, ZG Loewy - Pathogens, 2022 - mdpi.com
Chronic Obstructive Pulmonary Disease (COPD) is a progressive pulmonary disorder
underpinned by poorly reversible airflow resulting from chronic bronchitis or emphysema …

Pharmacologic therapies in patients with exacerbation of chronic obstructive pulmonary disease: a systematic review with meta-analysis

CC Dobler, AS Morrow, B Beuschel… - Annals of internal …, 2020 - acpjournals.org
Background: Chronic obstructive pulmonary disease (COPD) is characterized by frequent
exacerbations. Purpose: To evaluate the comparative effectiveness and adverse events …

Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages

S Chen, IE Kammerl, O Vosyka, T Baumann… - Cell Death & …, 2016 - nature.com
The proteasome is a central regulatory hub for intracellular signaling by degrading
numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes …

Heterogeneity of chronic obstructive pulmonary disease exacerbations: a two-axes classification proposal

JL Lopez-Campos, A Agustí - The Lancet Respiratory Medicine, 2015 - thelancet.com
Exacerbations of chronic obstructive pulmonary disease (COPD) are clinically relevant
events with therapeutic and prognostic implications. Yet, they are heterogeneous and can …