[HTML][HTML] Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria

H Zhong, H Yin - Redox biology, 2015 - Elsevier
Oxidative stress-induced lipid peroxidation has been associated with human physiology and
diseases including cancer. Overwhelming data suggest that reactive lipid mediators …

Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance

S Dalleau, M Baradat, F Guéraud, L Huc - Cell Death & Differentiation, 2013 - nature.com
During the last three decades, 4-hydroxy-2-nonenal (HNE), a major α, β-unsaturated
aldehyde product of n-6 fatty acid oxidation, has been shown to be involved in a great …

[HTML][HTML] On the role of 4-hydroxynonenal in health and disease

M Csala, T Kardon, B Legeza, B Lizák, J Mandl… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Polyunsaturated fatty acids are susceptible to peroxidation and they yield various
degradation products, including the main α, β-unsaturated hydroxyalkenal, 4-hydroxy-2, 3 …

Antioxidants and HNE in redox homeostasis

W Łuczaj, A Gęgotek, E Skrzydlewska - Free Radical Biology and Medicine, 2017 - Elsevier
Under physiological conditions, cells are in a stable state known as redox homeostasis,
which is maintained by the balance between continuous ROS/RNS generation and several …

Mechanisms linking colorectal cancer to the consumption of (processed) red meat: a review

D Demeyer, B Mertens, S De Smet… - Critical reviews in food …, 2016 - Taylor & Francis
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the world. The vast
majority of CRC cases have been linked to environmental causes rather than to heritable …

Multiscale structures of lipids in foods as parameters affecting fatty acid bioavailability and lipid metabolism

MC Michalski, C Genot, C Gayet, C Lopez, F Fine… - Progress in lipid …, 2013 - Elsevier
On a nutritional standpoint, lipids are now being studied beyond their energy content and
fatty acid (FA) profiles. Dietary FA are building blocks of a huge diversity of more complex …

Role of oxidative stress and Nrf2/KEAP1 signaling in colorectal cancer: mechanisms and therapeutic perspectives with phytochemicals

DY Lee, MY Song, EH Kim - Antioxidants, 2021 - mdpi.com
Colorectal cancer still has a high incidence and mortality rate, according to a report from the
American Cancer Society. Colorectal cancer has a high prevalence in patients with …

Mechanism of colorectal carcinogenesis triggered by heme iron from red meat

N Seiwert, D Heylmann, S Hasselwander… - Biochimica et Biophysica …, 2020 - Elsevier
Colorectal cancer (CRC) is one of the major tumor entities worldwide, with an increasing
incidence in younger people. CRC formation is causally linked to various genetic, life-style …

[HTML][HTML] Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron

N Seiwert, S Wecklein, P Demuth… - Cell death & …, 2020 - nature.com
The consumption of red meat is probably carcinogenic to humans and is associated with an
increased risk to develop colorectal cancer (CRC). Red meat contains high amounts of …

Lipid peroxidation linking diabetes and cancer: the importance of 4-hydroxynonenal

M Jaganjac, N Zarkovic - Antioxidants & redox signaling, 2022 - liebertpub.com
Significance: It is commonly believed that diabetes mellitus may be associated with cancer.
Hence, diabetic patients are at higher risk for hepatocellular carcinoma, pancreatic cancer …