BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

Hippocampal network operations supporting spatial navigation and declarative memory are
traditionally interpreted in a framework where each hippocampal area, such as the dentate …

The formation and retrieval of a memory is thought to be accomplished by activation and
reactivation, respectively, of the memory-holding cells (engram cells) by a common set of …

The mechanistic operation of brain regions is often interpreted by partitioning constituent
neurons into 'cell types'. Historically, such cell types were broadly defined by their …

The formation of long-lasting memories requires coordinated changes in gene expression
and protein synthesis. Although many studies implicate DNA modifications (DNA …

According to the encoding specificity hypothesis, memory is best recalled by retrieval cues
that overlap with training cues. Human studies generally support this hypothesis. However …

The hippocampal CA3 region is classically viewed as a homogeneous autoassociative
network critical for associative memory and pattern completion. However, recent evidence …

Social recognition memory is crucial for survival across species, underlying the need to
correctly identify conspecifics, mates and potential enemies. In humans the hippocampus is …

Highlights•Both granule cells and mossy cells contribute to DG pattern separation.•Studies
show functional dissociation along the CA3 transverse axis.•Similar to DG, proximal CA3 …

Scene and object information reach the entorhinal-hippocampal circuitry in partly
segregated cortical processing streams. Converging evidence suggests that such …