Both transcription and three-dimensional (3D) architecture of the mammalian genome play
critical roles in neurodevelopment and its disorders. However, 3D genome structures of …

Summary Single-cell (sc) RNA-seq, together with RNA velocity and metabolic labeling,
reveals cellular states and transitions at unprecedented resolution. Fully exploiting these …

The eukaryotic translation elongation factors (EEFs), ie EEF1A1, EEF1A2, EEF1B2, EEF1D,
EEF1G, EEF1E1 and EEF2, are coding-genes that play a central role in the elongation step …

Oogenesis is a complex developmental process that involves spatiotemporally regulated
coordination between the germline and supporting, somatic cell populations. This process …

Single-cell multiomics technologies empower simultaneous measurement of multiple types
of molecules within individual cells, providing a more profound comprehension compared …

Recent advances in single-cell assay for transposase accessible chromatin using
sequencing (scATAC-seq) and its coassays have transformed the field of single-cell …

Physiological processes, such as the epithelial–mesenchymal transition (EMT), are
mediated by changes in protein interactions. These changes may be better reflected in …

Amyloid-β (Aβ) and tau proteins accumulate within distinct neuronal systems in Alzheimer's
disease (AD). Although it is not clear why certain brain regions are more vulnerable to Aβ …

Single-cell proteomics has attracted a lot of attention in recent years because it offers more
functional relevance than single-cell transcriptomics. However, most work to date has …

Comprehensive biomedical proteomic datasets are accumulating exponentially, warranting
robust analytics to deconvolute them for identifying novel biological insights. Here, we report …