Our understanding of human colonic motility, and autonomic reflexes that generate motor
patterns, has increased markedly through high-resolution manometry. Details of the motor …

Eating and drinking generate sequential mechanosensory signals along the digestive tract.
These signals are communicated to the brain for the timely initiation and regulation of …

INTRODUCTION A reference atlas of human cell types is a major goal for the field. Here, we
set out to generate single-cell atlases of both gene expression (this study) and chromatin …

Gastrointestinal (GI) discomfort is a hallmark of most gut disorders and represents an
important component of chronic visceral pain. For the growing population afflicted by irritable …

Sensory neurons relay gut-derived signals to the brain, yet the molecular and functional
organization of distinct populations remains unclear. Here, we employed intersectional …

Mechanisms resulting in abdominal pain include altered neuro-immune interactions in the
gastrointestinal tract, but the signaling processes that link immune activation with visceral …

The properties of dorsal root ganglia (DRG) neurons that innervate the distal colon are
poorly defined, hindering our understanding of their roles in normal physiology and …

Gastrointestinal (GI) vagal afferents convey sensory signals from the GI tract to the brain.
Numerous subtypes of GI vagal afferent have been identified but their individual roles in gut …

Increasing evidence links the gut microbiome and the nervous system in health and disease.
This narrative review discusses current views on the interaction between the gut microbiota …

Background & Aims Chronic abdominal pain is a common symptom of inflammatory bowel
diseases (IBDs). Peripheral and central mechanisms contribute to the transition from acute …