Background Conventional meta-analyses have shown inconsistent results for efficacy of
second-generation antidepressants. We therefore did a multiple-treatments meta-analysis …

Background: Second-generation antidepressants dominate the management of major
depressive disorder (MDD), but evidence on the comparative benefits and harms of these …

The issue of the severity of psychiatric disorders has great clinical importance. For example,
severity influences decisions about level of care, and affects decisions to seek government …

Depression is one of the most common and debilitating psychiatric disorders and is a
leading cause of suicide. Most people who become depressed will have multiple episodes …

Weight gain during antidepressant treatment can be either a sign of improvement in patients
who have weight loss as a symptom of depression or a residual symptom in patients who …

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According to the DSM-IV classification, a diagnosis of Major Depressive Disorder (MDD) is
possible only when there is evidence of significant inference with functioning. However …

Most antidepressants change sleep; in particular, they alter the physiological patterns of
sleep stages recorded overnight with EEG and other physiological measures. These effects …

Major depression is a heterogeneous condition, and the search for neural correlates specific
to clinically defined subtypes has been inconclusive. Theoretical considerations implicate …

Background Mirtazapine has a unique mechanism of antidepressive action and is one of the
commonly used antidepressants in clinical practice. Objectives The aim of the present …