[HTML][HTML] Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity
V Volarevic, B Djokovic, MG Jankovic… - Journal of biomedical …, 2019 - Springer
Background Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective
chemotherapeutic agents. However, its clinical use is limited due to the severe side effects …
chemotherapeutic agents. However, its clinical use is limited due to the severe side effects …
[HTML][HTML] Protective role for antioxidants in acute kidney disease
JM Dennis, PK Witting - Nutrients, 2017 - mdpi.com
Acute kidney injury causes significant morbidity and mortality in the community and clinic.
Various pathologies, including renal and cardiovascular disease, traumatic …
Various pathologies, including renal and cardiovascular disease, traumatic …
Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells
O Adedoyin, R Boddu, A Traylor… - American Journal …, 2018 - journals.physiology.org
Ferroptosis is an iron-dependent form of regulated nonapoptotic cell death, which
contributes to damage in models of acute kidney injury (AKI). Heme oxygenase-1 (HO-1) is a …
contributes to damage in models of acute kidney injury (AKI). Heme oxygenase-1 (HO-1) is a …
Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor–induced dipeptidase-1 expression and glutathione depletion
A von Mässenhausen, N Zamora Gonzalez… - Science …, 2022 - science.org
Dexamethasone is widely used as an immunosuppressive therapy and recently as COVID-
19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of …
19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of …
Renal inflammation and fibrosis: a double-edged sword
Renal tissue injury initiates inflammatory and fibrotic processes that occur to promote
regeneration and repair. After renal injury, damaged tissue releases cytokines and …
regeneration and repair. After renal injury, damaged tissue releases cytokines and …
The cross‐link between ferroptosis and kidney diseases
J Wang, Y Liu, Y Wang, L Sun - Oxidative Medicine and …, 2021 - Wiley Online Library
Acute and chronic kidney injuries result from structural dysfunction and metabolic disorders
of the kidney in various etiologies, which significantly affect human survival and social …
of the kidney in various etiologies, which significantly affect human survival and social …
Programmed necrosis and disease: we interrupt your regular programming to bring you necroinflammation
Compared to the tidy and immunologically silent death during apoptosis, necrosis seems
like a chaotic and unorganized demise. However, we now recognize that there is a method …
like a chaotic and unorganized demise. However, we now recognize that there is a method …
[HTML][HTML] The predictive role of the biomarker kidney molecule-1 (KIM-1) in acute kidney injury (AKI) cisplatin-induced nephrotoxicity
Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently
reported serious side-effect. However, there are no approved biomarkers that can properly …
reported serious side-effect. However, there are no approved biomarkers that can properly …
[HTML][HTML] Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier
J Hauptmann, L Johann, F Marini, M Kitic… - Acta …, 2020 - Springer
The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of
multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis …
multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis …
[HTML][HTML] Modulation of oxidative stress by ozone therapy in the prevention and treatment of chemotherapy-induced toxicity: review and prospects
(1) Background: Cancer is one of the leading causes of mortality worldwide. Radiotherapy
and chemotherapy attempt to kill tumor cells by different mechanisms mediated by an …
and chemotherapy attempt to kill tumor cells by different mechanisms mediated by an …