Background Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective
chemotherapeutic agents. However, its clinical use is limited due to the severe side effects …

Acute kidney injury causes significant morbidity and mortality in the community and clinic.
Various pathologies, including renal and cardiovascular disease, traumatic …

Ferroptosis is an iron-dependent form of regulated nonapoptotic cell death, which
contributes to damage in models of acute kidney injury (AKI). Heme oxygenase-1 (HO-1) is a …

Dexamethasone is widely used as an immunosuppressive therapy and recently as COVID-
19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of …

Renal tissue injury initiates inflammatory and fibrotic processes that occur to promote
regeneration and repair. After renal injury, damaged tissue releases cytokines and …

Acute and chronic kidney injuries result from structural dysfunction and metabolic disorders
of the kidney in various etiologies, which significantly affect human survival and social …

Compared to the tidy and immunologically silent death during apoptosis, necrosis seems
like a chaotic and unorganized demise. However, we now recognize that there is a method …

Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently
reported serious side-effect. However, there are no approved biomarkers that can properly …

The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of
multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis …

(1) Background: Cancer is one of the leading causes of mortality worldwide. Radiotherapy
and chemotherapy attempt to kill tumor cells by different mechanisms mediated by an …