The ichthyoses are a large, heterogeneous group of skin cornification disorders. They can
be inherited or acquired, and result in defective keratinocyte differentiation and abnormal …

Recent progress in the genetics of autosomal recessive congenital ichthyosis (ARCI) has
illustrated the power of genetic strategies for the investigation of newly recognized metabolic …

Consumption of dietary lipids, such as cholesterol, modulates the gut microbiome with
consequences for host health through the production of microbiome-derived metabolites …

Inherited ichthyoses are classified as Mendelian disorders of cornification (MEDOC), which
are defined on the basis of clinical and genetic features and are mainly divided into non …

Background Recessive forms of congenital ichthyosis encompass a group of rare inherited
disorders of keratinization leading to dry, scaly skin. So far, 13 genes have been implicated …

Autosomal recessive congenital ichthyosis (ARCI), a phenotypically heterogeneous group of
non‐syndromic Mendelian disorders of keratinization, is caused by mutations in as many as …

Sulfotransferases (SULTs) are Phase II drug-metabolizing enzymes (DMEs) catalyzing the
sulfation of a variety of endogenous compounds, natural products, and drugs. Various drugs …

Mutations in genes such as transglutaminase-1 (TGM1), which are responsible for the
formation and normal functioning of a lipid barrier, lead to the development of autosomal …

Abstract Introduction Cytosolic sulfotransferases (SULTs)-mediated sulfation is critically
involved in the metabolism of key endogenous compounds, such as catecholamines and …

The autosomal recessive congenital ichthyoses (ARCI) are a nonsyndromic group of
cornification disorders that includes lamellar ichthyosis, congenital ichthyosiform …