Cell spheroids (esp. organoids) as 3D culture platforms are popular models for representing
cell–cell and cell–extracellular matrix (ECM) interactions, bridging the gap between 2D cell …

Stem cells (SCs) have been used therapeutically for decades, yet their applications are
limited by factors such as the risk of immune rejection and potential tumorigenicity …

Human naïve pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts
termed blastoids upon switch to inductive medium. However, the underlying mechanisms …

Neonatal spinal cord tissues exhibit remarkable regenerative capabilities as compared to
adult spinal cord tissues after injury, but the role of extracellular matrix (ECM) in this process …

The use of stem cells to model the early human embryo promises to transform our
understanding of developmental biology and human reproduction. In this review, we present …

Cell adhesion to the extracellular matrix (ECM) is required for normal cell cycle progression
and accurate cell division. However, how cell adhesion to the wide range of ECM proteins …

Recent breakthroughs in developing human-relevant organotypic models led to the building
of highly resemblant tissue constructs that hold immense potential for transplantation, drug …

The discovery of mouse embryonic stem cells in 1981 transformed research in mammalian
developmental biology and functional genomics. The subsequent generation of human …

Mesenchymal stem cell (MSC) transplantation has been explored for the clinical treatment of
various diseases. However, the current two-dimensional (2D) culture method lacks a natural …

In vitro-generated blastocyst-like structures are of great importance since they recapitulate
specific features or processes of early embryogenesis, thus avoiding ethical concerns as …