Highlights•Pili minor components play a key role in the regulation of pili mediated
activities.•Adhesion is a multifactorial effect; adhesins may function in an orchestrated …

The complement system is a key component of innate immunity which readily responds to
invading microorganisms. Activation of the complement system typically occurs via three …

Neisseria gonorrhoeae causes the sexually transmitted infection gonorrhea, while Neisseria
meningitidis is an important cause of bacterial meningitis and sepsis. Complement is a …

Neuromyelitis optica (NMO) spectrum disorders (SD) represent an evolving group of central
nervous system (CNS)-inflammatory autoimmune demyelinating diseases unified by a …

Neisseria meningitidis can be a human commensal in the upper respiratory tract but is also
capable of causing invasive diseases such as meningococcal meningitis and septicaemia …

Among 25 serogroup B Neisseria meningitidis clinical isolates, we identified four (16%) with
high factor H binding protein (FHbp) expression that were resistant to complement-mediated …

For decades, there was no licensed vaccine for prevention of endemic capsular group B
meningococcal disease, despite the availability of vaccines for prevention of the other most …

The emergence of antimicrobial resistance among several medically important pathogens
represents a serious threat to human health globally and necessitates the development of …

MenB-FHbp is a meningococcal serogroup B vaccine with two factor H binding protein
(FHbp) antigens from subfamilies A and B. For licensure, efficacy was inferred from serum …

The outer membrane of a gram-negative bacteria encapsulates the plasma membrane
thereby protecting it from the harsh external environment. This membrane acts as a sieving …