Hypertension is a leading risk factor for stroke, heart disease and chronic kidney disease.
Multiple interacting factors and organ systems increase blood pressure and cause target …

Myocardial remodeling is a key pathophysiological basis of heart failure, which seriously
threatens human health and causes a severe economic burden worldwide. During chronic …

Importance Longer leukocyte telomere length (LTL) is associated with a lower risk of
adverse cardiovascular outcomes. The extent to which variation in LTL is associated with …

Background Reliable predictors of treatment efficacy in heart failure have been long
awaited. DNA damage has been implicated as a cause of heart failure. Objectives The …

Essential or primary hypertension is a wordwide health problem. Elevated blood pressure
(BP) is closely associated not only with increased chronological aging but also with …

Previous studies have demonstrated that bone morphogenetic proteins (BMPs) play
important roles in cardiovascular diseases, including atherosclerosis, artery calcification …

Neuroinflammation and oxidative stress induced by intermittent hypoxia (IH) are associated
with cognitive dysfunction in patients with obstructive sleep apnea (OSA). Recently, TAR …

Significance: Reactive oxygen species (ROS) play a key role in the pathogenesis of cardiac
remodeling and the subsequent progression to heart failure (HF). Nicotinamide adenosine …

Histone deacetylases (HDACs) play critical roles in cardiovascular diseases (CVDs). In
addition, reactive oxygen species (ROS) produced by NADPH oxidases (NOXs) exert …

The aging process is accompanied by a continuous decline of the cardiac system, disrupting
the homeostatic regulation of cells, organs, and systems. Aging increases the prevalence of …