Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

The neuroethics of disorders of consciousness: a brief history of evolving ideas

MJ Young, YG Bodien, JT Giacino, JJ Fins, RD Truog… - Brain, 2021 - academic.oup.com
Neuroethical questions raised by recent advances in the diagnosis and treatment of
disorders of consciousness are rapidly expanding, increasingly relevant and yet …

Therapies to restore consciousness in patients with severe brain injuries: a gap analysis and future directions

BL Edlow, LRD Sanz, L Polizzotto, N Pouratian… - Neurocritical care, 2021 - Springer
Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …

Measuring consciousness in the intensive care unit

BL Edlow, M Fecchio, YG Bodien, A Comanducci… - Neurocritical Care, 2023 - Springer
Early reemergence of consciousness predicts long-term functional recovery for patients with
severe brain injury. However, tools to reliably detect consciousness in the intensive care unit …

Mapping the subcortical connectivity of the human default mode network

J Li, WH Curley, B Guerin, DD Dougherty, AV Dalca… - Neuroimage, 2021 - Elsevier
The default mode network (DMN) mediates self-awareness and introspection, core
components of human consciousness. Therapies to restore consciousness in patients with …

Update on neuroimaging in disorders of consciousness

LRD Sanz, A Thibaut, BL Edlow… - Current opinion in …, 2021 - journals.lww.com
Each neuroimaging technique conveys advantages and pitfalls to assess consciousness.
We recommend a multimodal approach in which complementary techniques provide …

Proceedings of the first curing coma campaign NIH symposium: challenging the future of research for coma and disorders of consciousness

J Claassen, Y Akbari, S Alexander, MK Bader, K Bell… - Neurocritical care, 2021 - Springer
Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden
for patients, families, and society worldwide. As part of the Curing Coma Campaign, the …

Multimodal MRI reveals brainstem connections that sustain wakefulness in human consciousness

BL Edlow, M Olchanyi, HJ Freeman, J Li… - Science Translational …, 2024 - science.org
Consciousness is composed of arousal (ie, wakefulness) and awareness. Substantial
progress has been made in mapping the cortical networks that underlie awareness in the …

Common data elements for disorders of consciousness: Recommendations from the working group on neuroimaging

BL Edlow, VL Boerwinkle, J Annen, M Boly… - Neurocritical care, 2023 - Springer
Background Over the past 5 decades, advances in neuroimaging have yielded insights into
the pathophysiologic mechanisms that cause disorders of consciousness (DoC) in patients …

Proceedings of the second curing coma campaign NIH symposium: challenging the future of research for coma and disorders of consciousness

S Mainali, V Aiyagari, S Alexander, Y Bodien… - Neurocritical care, 2022 - Springer
This proceedings article presents actionable research targets on the basis of the
presentations and discussions at the 2nd Curing Coma National Institutes of Health (NIH) …