The world is facing a significant increase in infections caused by drug-resistant infectious
agents. In response, various strategies have been recently explored to treat them, including …

The major constituent of the outer membrane of Gram-negative bacteria is
lipopolysaccharide (LPS), which is comprised of lipid A, core oligosaccharide, and O …

Pseudomonas aeruginosa is a complex gram-negative facultative anaerobe replete with a
variety of arsenals to activate, modify, and destroy host defense mechanisms. The microbe is …

Antibiotics have had a profound impact on human society by enabling the eradication of
otherwise deadly infections. Unfortunately, antibiotic use and overuse has led to the rapid …

Lipopolysaccharides (LPSs) are a constitutive element of the cell envelope of Gram-
negative bacteria, representing the main lipid in the external leaflet of their outer membrane …

Antimicrobial peptides and proteins (APPs) are becoming increasingly important in targeting
multidrug-resistant (MDR) bacteria. APPs is a rapidly emerging area with novel molecules …

The prevalence of multidrug-resistant Pseudomonas aeruginosa has stimulated
development of alternative therapeutics. Bacteriophage peptidoglycan hydrolases, termed …

Unlike their descendants, mitochondria and plastids, bacteria do not have dedicated protein
import systems. However, paradoxically, import of protein bacteriocins, the mechanisms of …

Pseudomonas aeruginosa (P. aeruginosa) infection has become an intractable problem
worldwide due to the decreasing efficacy of the mainstay therapy, antibiotic treatment …

ABSTRACT Pyocin S5 (PyoS5) is a potent protein bacteriocin that eradicates the human
pathogen Pseudomonas aeruginosa in animal infection models, but its import mechanism is …