With the advance in science and technology as well as the improvement of living standards,
the function of food is no longer just to meet the needs of survival. Food science and its …

Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity worldwide
leading to 31% of all global deaths. Early prediction and prevention could greatly reduce the …

Mammalian organs continually exchange metabolites via circulation, but systems-level
analysis of this shuttling process is lacking. Here, we compared, in fasted pigs, metabolite …

The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …

Understanding genetic architecture of plasma lipidome could provide better insights into
lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome …

Dysregulation of lipid homeostasis is a precipitating event in the pathogenesis and
progression of hepatosteatosis and metabolic syndrome. These conditions are highly …

Bile acids (BAs) are complex and incompletely understood enterohepatic-derived hormones
that control whole-body metabolism. Here, we profiled postprandial BAs in the liver, feces …

Lipids in bovine milk have several biological activities, with implications for human health
and the physical functionality of foods. However, alterations in the lipid profile of bovine milk …

Cellular exposure to free fatty acids (FFAs) is implicated in the pathogenesis of obesity-
associated diseases. However, there are no scalable approaches to comprehensively …

Despite the crucial roles of lipids in metabolism, we are still at the early stages of
comprehensively annotating lipid species and their genetic basis. Mass spectrometry–based …