Staphylococcus aureus is a common human pathogen. Methicillin-resistant Staphylococcus
aureus (MRSA) infections pose significant and challenging therapeutic difficulties. MRSA …

Antimicrobial resistance (AMR) is a complex threat to human health and, to date, it
represents a hot topic in drug discovery. The use of non-antibiotic molecules to block …

The discovery void of antimicrobial development has occurred at a time when the world has
seen a rapid emergence and spread of antimicrobial resistance, the 'perfect storm'as it has …

The bacterial species Staphylococcus aureus presents a variety of resistance mechanisms,
among which the expression of β-lactamases and efflux pumps stand out for providing a …

The ongoing development of novel strategies to combat Staphylococcus aureus and
eliminate its biofilm formation has gained significant attention for human health. Antibiotic …

Overexpression of the efflux pump is a predominant mechanism by which bacteria show
antimicrobial resistance (AMR) and leads to the global emergence of multidrug resistance …

Quinazoline and quinazolinone derivatives piqued medicinal chemistry interest in
developing novel drug candidates owing to their pharmacological potential. They are …

Antimicrobial resistance has emerged as a covert global health crisis, posing a significant
threat to humanity. If left unaddressed, it is poised to become the foremost cause of mortality …

Nontuberculous mycobacteria (NTM), which include the Mycobacterium avium complex, are
classified as difficult‐to‐treat pathogens due to their ability to quickly develop drug …

One promising approach in treating antibiotic-resistant bacteria is to “break” resistances
connected with antibacterial efflux by co-administering efflux pump inhibitors (EPIs) with …