Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation
M Jia, Y Wang, J Wang, D Qin, M Wang, L Chai… - Nature …, 2023 - nature.com
Stimulator of interferon gene (STING)-triggered autophagy is crucial for the host to eliminate
invading pathogens and serves as a self-limiting mechanism of STING-induced interferon …
invading pathogens and serves as a self-limiting mechanism of STING-induced interferon …
Acylation in trypanosomatids: an essential process and potential drug target
Fatty acylation—the addition of fatty acid moieties such as myristate and palmitate to
proteins—is essential for the survival, growth, and infectivity of the trypanosomatids …
proteins—is essential for the survival, growth, and infectivity of the trypanosomatids …
Serine/threonine protein kinase STK16
J Wang, X Ji, J Liu, X Zhang - International journal of molecular sciences, 2019 - mdpi.com
STK16 (Ser/Thr kinase 16, also known as Krct/PKL12/MPSK1/TSF-1) is a myristoylated and
palmitoylated Ser/Thr protein kinase that is ubiquitously expressed and conserved among …
palmitoylated Ser/Thr protein kinase that is ubiquitously expressed and conserved among …
[HTML][HTML] N-myristoyltransferase-1 deficiency blocks myristoylation of LAMTOR1 and inhibits bladder cancer progression
Y Sun, Z Guan, Q Sheng, W Duan, H Zhao, J Zhou… - Cancer letters, 2022 - Elsevier
Abstract N-myristoyltransferase-1 (NMT1) catalyzes protein posttranslational myristoylation
and functions as an oncogene in various cancers, although its roles in bladder cancer …
and functions as an oncogene in various cancers, although its roles in bladder cancer …
Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein
X Carnec, V Borges-Cardoso, S Reynard… - PLoS …, 2024 - journals.plos.org
Several Old World and New World Mammarenavirus are responsible for hemorrhagic fever
in humans. These enveloped viruses have a bi-segmented ambisense RNA genome that …
in humans. These enveloped viruses have a bi-segmented ambisense RNA genome that …
A statistical method for image-mediated association studies discovers genes and pathways associated with four brain disorders
Brain imaging and genomics are critical tools enabling characterization of the genetic basis
of brain disorders. However, imaging large cohorts is expensive and may be unavailable for …
of brain disorders. However, imaging large cohorts is expensive and may be unavailable for …
Analysis of the effect of intestinal ischemia and reperfusion on the rat neutrophils proteome
Intestinal ischemia and reperfusion injury is a model system of possible consequences of
severe trauma and surgery, which might result into tissue dysfunction and organ failure …
severe trauma and surgery, which might result into tissue dysfunction and organ failure …
[HTML][HTML] Tris DBA palladium is an orally available inhibitor of GNAQ mutant uveal melanoma in vivo
E Musi, GK Schwartz, JH Yoo, SJ Odelberg, DY Li… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Uveal melanoma is a rare but often lethal malignancy and is the leading cause of death due
to an ophthalmic condition. Uveal melanoma is often diagnosed at a late stage and has a …
to an ophthalmic condition. Uveal melanoma is often diagnosed at a late stage and has a …
Impairment of a membrane-targeting protein translated from a downstream gene of a “self-cleaving” T2A peptide conjunction
S Hadpech, W Jinathep, S Saoin, W Thongkum… - Protein Expression and …, 2018 - Elsevier
The requirement for reliable bicistronic or multicistronic vectors in gene delivery systems is
at the forefront of bio/biomedical technology. A method that provides an efficient co …
at the forefront of bio/biomedical technology. A method that provides an efficient co …
TNF-α-induced Inhibition of Protein Myristoylation Via Binding Between NMT1 and Sorbs2 in Osteoblasts
S Kutsuna, G Sugiyama, T Komiyama, H Kamohara… - in vivo, 2024 - iv.iiarjournals.org
Background/Aim: Bone resolution due to tumor invasion often occurs on the surface of the
jaw and is important for clinical prognosis. Although cytokines, such as TNF-α are known to …
jaw and is important for clinical prognosis. Although cytokines, such as TNF-α are known to …