Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation

M Jia, Y Wang, J Wang, D Qin, M Wang, L Chai… - Nature …, 2023 - nature.com
Stimulator of interferon gene (STING)-triggered autophagy is crucial for the host to eliminate
invading pathogens and serves as a self-limiting mechanism of STING-induced interferon …

Acylation in trypanosomatids: an essential process and potential drug target

AM Goldston, AI Sharma, KS Paul, DM Engman - Trends in parasitology, 2014 - cell.com
Fatty acylation—the addition of fatty acid moieties such as myristate and palmitate to
proteins—is essential for the survival, growth, and infectivity of the trypanosomatids …

Serine/threonine protein kinase STK16

J Wang, X Ji, J Liu, X Zhang - International journal of molecular sciences, 2019 - mdpi.com
STK16 (Ser/Thr kinase 16, also known as Krct/PKL12/MPSK1/TSF-1) is a myristoylated and
palmitoylated Ser/Thr protein kinase that is ubiquitously expressed and conserved among …

[HTML][HTML] N-myristoyltransferase-1 deficiency blocks myristoylation of LAMTOR1 and inhibits bladder cancer progression

Y Sun, Z Guan, Q Sheng, W Duan, H Zhao, J Zhou… - Cancer letters, 2022 - Elsevier
Abstract N-myristoyltransferase-1 (NMT1) catalyzes protein posttranslational myristoylation
and functions as an oncogene in various cancers, although its roles in bladder cancer …

Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein

X Carnec, V Borges-Cardoso, S Reynard… - PLoS …, 2024 - journals.plos.org
Several Old World and New World Mammarenavirus are responsible for hemorrhagic fever
in humans. These enveloped viruses have a bi-segmented ambisense RNA genome that …

A statistical method for image-mediated association studies discovers genes and pathways associated with four brain disorders

J He, L Antonyan, H Zhu, K Ardila, Q Li… - The American Journal of …, 2024 - cell.com
Brain imaging and genomics are critical tools enabling characterization of the genetic basis
of brain disorders. However, imaging large cohorts is expensive and may be unavailable for …

Analysis of the effect of intestinal ischemia and reperfusion on the rat neutrophils proteome

M Tahir, S Arshid, B Fontes, MS Castro… - Frontiers in Molecular …, 2018 - frontiersin.org
Intestinal ischemia and reperfusion injury is a model system of possible consequences of
severe trauma and surgery, which might result into tissue dysfunction and organ failure …

[HTML][HTML] Tris DBA palladium is an orally available inhibitor of GNAQ mutant uveal melanoma in vivo

E Musi, GK Schwartz, JH Yoo, SJ Odelberg, DY Li… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Uveal melanoma is a rare but often lethal malignancy and is the leading cause of death due
to an ophthalmic condition. Uveal melanoma is often diagnosed at a late stage and has a …

Impairment of a membrane-targeting protein translated from a downstream gene of a “self-cleaving” T2A peptide conjunction

S Hadpech, W Jinathep, S Saoin, W Thongkum… - Protein Expression and …, 2018 - Elsevier
The requirement for reliable bicistronic or multicistronic vectors in gene delivery systems is
at the forefront of bio/biomedical technology. A method that provides an efficient co …

TNF-α-induced Inhibition of Protein Myristoylation Via Binding Between NMT1 and Sorbs2 in Osteoblasts

S Kutsuna, G Sugiyama, T Komiyama, H Kamohara… - in vivo, 2024 - iv.iiarjournals.org
Background/Aim: Bone resolution due to tumor invasion often occurs on the surface of the
jaw and is important for clinical prognosis. Although cytokines, such as TNF-α are known to …