[HTML][HTML] Chronic cough: new insights and future prospects

A Morice, P Dicpinigaitis, L McGarvey… - European Respiratory …, 2021 - Eur Respiratory Soc
Chronic cough is defined in adults as a cough that lasts for≥ 8 weeks. When it proves
intractable to standard-of-care treatment, it can be referred to as refractory chronic cough …

Mechanisms and rationale for targeted therapies in refractory and unexplained chronic cough

SB Mazzone, L McGarvey - Clinical Pharmacology & …, 2021 - Wiley Online Library
Chronic cough, defined as a cough lasting> 8 weeks, is a common medical condition that
exerts a substantial physical, mental, and social burden on patients. A subset of patients with …

Global physiology and pathophysiology of cough: part 1: cough phenomenology–CHEST guideline and expert panel report

KK Lee, PW Davenport, JA Smith, RS Irwin… - Chest, 2021 - Elsevier
The purpose of this state-of-the-art review is to update the American College of Chest
Physicians 2006 guideline on global physiology and pathophysiology of cough. A review of …

Management of chronic refractory cough in adults

D Visca, B Beghè, LM Fabbri, A Papi… - European Journal of …, 2020 - Elsevier
Cough is a common respiratory symptom that is considered to be chronic when it lasts more
than eight weeks. When severe, chronic cough may significantly impact an individual's …

Voltage-gated sodium channels: structures, functions, and molecular modeling

L Xu, X Ding, T Wang, S Mou, H Sun, T Hou - Drug discovery today, 2019 - Elsevier
Highlights•The structures and functions of VGSCs are briefly outlined.•The major binding
sites and isoform-selective modulators of VGSCs are summarized.•The studies on the …

[HTML][HTML] Validation and meaningful change thresholds for an objective cough frequency measurement in chronic cough

J Schelfhout, AM Nguyen, SS Birring, ED Bacci… - Lung, 2022 - Springer
Purpose Objective cough frequency is used to assess efficacy of chronic cough (CC)
treatments. The objective of this study was to explore the relationship between objective …

[HTML][HTML] Chronic cough—the limitation and advances in assessment techniques

M Zhang, DL Sykes, K Brindle… - Journal of Thoracic …, 2022 - ncbi.nlm.nih.gov
Accurate and consistent assessments of cough are essential to advance the understanding
of the mechanisms of cough and individualised the management of patients. Considerable …

Treatment of chronic cough: P2X3 receptor antagonists and beyond

DL Sykes, M Zhang, AH Morice - Pharmacology & Therapeutics, 2022 - Elsevier
For years chronic cough (CC) has presented an enormous physical, psychological, and
social burden on those who experience it, with no approved pharmacological therapies to …

[HTML][HTML] Prevalence of chronic cough in China: a systematic review and meta-analysis

H Liang, W Ye, Z Wang, J Liang, F Yi, M Jiang… - BMC Pulmonary …, 2022 - Springer
Background Individual studies have indicated variable prevalence for chronic cough, but
thus far, there has been no systematic report on the prevalence of this condition. Methods In …

Translational review: neuroimmune mechanisms in cough and emerging therapeutic targets

AE McGovern, KR Short, AAK Moe… - Journal of Allergy and …, 2018 - Elsevier
Cough is an essential defensive behavior for maintaining airway patency and to protect the
lungs from potentially harmful agents. However, inflammatory pathologies can sensitize and …