Synthetic cannabinoids: a pharmacological and toxicological overview
R Roque-Bravo, RS Silva, RF Malheiro… - Annual review of …, 2023 - annualreviews.org
Synthetic cannabinoids (SCs) are a chemically diverse group of new psychoactive
substances (NPSs) that target the endocannabinoid system, triggering a plethora of actions …
substances (NPSs) that target the endocannabinoid system, triggering a plethora of actions …
Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds
Traumatic brain injury is common, and often results in debilitating consequences. Even mild
traumatic brain injury leaves approximately 20% of patients with symptoms that persist for …
traumatic brain injury leaves approximately 20% of patients with symptoms that persist for …
From JWH‐018 to OXIZIDS: structural evolution of synthetic cannabinoids in the European Union from 2008 to present day
R Andrews, R Jorge, R Christie… - Drug testing and …, 2023 - Wiley Online Library
With new synthetic cannabinoids (SCs) appearing on the European drug market every year,
early warning systems are key to detect, monitor, and respond to threats posed by them. The …
early warning systems are key to detect, monitor, and respond to threats posed by them. The …
Instant detection of synthetic cannabinoids on physical matrices, implemented on a low-cost, ultraportable device
GE Cozier, RC Andrews, A Frinculescu… - Analytical …, 2023 - ACS Publications
Synthetic cannabinoids (SCs) make up a class of novel psychoactive substances (NPS),
used predominantly in prisons and homeless communities in the UK SCs can have severe …
used predominantly in prisons and homeless communities in the UK SCs can have severe …
Subtle Structural Modification of a Synthetic Cannabinoid Receptor Agonist Drastically Increases its Efficacy at the CB1 Receptor
H Yano, R Chitsazi, C Lucaj, P Tran… - ACS chemical …, 2023 - ACS Publications
The emergence of synthetic cannabinoid receptor agonists (SCRAs) as illicit psychoactive
substances has posed considerable public health risks, including fatalities. Many SCRAs …
substances has posed considerable public health risks, including fatalities. Many SCRAs …
Defining Steric Requirements at CB1 and CB2 Cannabinoid Receptors Using Synthetic Cannabinoid Receptor Agonists 5F-AB-PINACA, 5F-ADB-PINACA, PX-1, PX …
J Markham, E Sparkes, R Boyd, S Chen… - ACS Chemical …, 2022 - ACS Publications
Synthetic cannabinoid receptor agonists (SCRAs) are a diverse class of new psychoactive
substances (NPS). They commonly comprise N-alkylated indole, indazole, or 7-azaindole …
substances (NPS). They commonly comprise N-alkylated indole, indazole, or 7-azaindole …
Micro-paper-based analytical device decorated with metal-organic frameworks for the assay of synthetic cannabinoids in oral fluids coupled to ion mobility …
H Martínez-Pérez-Cejuela, P García-Atienza… - Microchimica Acta, 2023 - Springer
A new concept of paper-based device has been developed combining the advantages of
cellulose supports and the rich surface chemistry of metal-organic frameworks (MOFs). The …
cellulose supports and the rich surface chemistry of metal-organic frameworks (MOFs). The …
Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB2 receptor
The rapid structural evolution and emergence of novel synthetic cannabinoid receptor
agonists (SCRAs) in the recreational market remains a key public health concern. Despite …
agonists (SCRAs) in the recreational market remains a key public health concern. Despite …
Progress on the development of Class A GPCR‐biased ligands
P Morales, MM Scharf, M Bermudez… - British Journal of …, 2024 - Wiley Online Library
Class AG protein‐coupled receptors (GPCRs) continue to garner interest for their essential
roles in cell signalling and their importance as drug targets. Although numerous drugs in the …
roles in cell signalling and their importance as drug targets. Although numerous drugs in the …
[HTML][HTML] Investigating selectivity and bias for G protein subtypes and β-arrestins by synthetic cannabinoid receptor agonists at the cannabinoid CB1 receptor
The cannabinoid CB 1 receptor (CB 1) is a G protein-coupled receptor (GPCR) with
widespread expression in the central nervous system. This canonically G⍺ i/o-coupled …
widespread expression in the central nervous system. This canonically G⍺ i/o-coupled …