A critical review of the development of specific chemotherapeutic approaches for the
management of American Trypanosomiasis or Chagas disease is presented, including …

Parasitic and bacterial infections affecting the gastrointestinal tract represent a significant
cause of morbidity and mortality worldwide. Nitroheterocyclic drugs have been available …

The parasites that give rise to human African trypanosomiasis (HAT) are auxotrophs for
various nutrients from the human host, including purines. They have specialist nucleoside …

With the aim of determining the actual target (s) of nitro-group bearing compounds
considered as possible leads for the development of drugs against Chagas' disease, we …

Sleeping sickness is resurgent in Africa. Adverse side-effects and drug-resistance are
undermining the few drugs currently licensed for use against this disease, which is caused …

Nitrocompounds are bioactive molecules used as antibacterial, antiparasitic and antitumoral
agents. In the past of years, these molecules have been broadly studied in several fields …

ABSTRACT A series of nitroheterocyclic compounds were designed with linkages to
melamine or benzamidine groups that are known substrates of the P2 aminopurine and …

Cyto-and genotoxicity induced by drugs can limit the dose and duration of treatment, can
adversely affect patient quality of life, and may be life-threatening. Two drugs are currently …

Chemotherapy for human African trypanosomiasis (HAT), or sleeping sickness, is unreliable
because of resistance, refraction and toxic and adverse side‐effects. Using a long‐term …

Megazol (7) is a 5-nitroimidazole that is highly active against Trypanosoma cruzi and
Trypanosoma brucei, as well as drug-resistant forms of trypanosomiasis. Compound 7 is not …