Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen
species (ROS) play contradicting roles in cancer incidence and progression. Antioxidants …

Dysregulated cell division, which leads to aberrant cell proliferation, is one of the key
hallmarks of cancer. Therefore, therapeutic targets that block cell division would be effective …

Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose catalytic activities are
regulated by interactions with cyclins and CDK inhibitors (CKIs). CDKs are key regulatory …

Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant
activity of various cell cycle proteins. Therefore, cell cycle regulators are considered …

Cyclins and cyclin-dependent protein kinases (CDKs) are important proteins that are
required for the regulation and expression of the large number of components necessary for …

Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as
promising candidate targets for cancer treatment. These proteins complexed with cyclins …

Flavonoids, which are polyphenolic compounds, are a class of plant secondary metabolites
possessing a broad spectrum of pharmacological activity including anti-cancer activities …

Background Patients with chronic lymphocytic leukaemia (CLL) with TP53 aberrations
respond poorly to first-line chemoimmunotherapy, resulting in early relapse and short …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …