[HTML][HTML] CD8+ T cells in HIV control, cure and prevention
HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
[HTML][HTML] Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
[HTML][HTML] Phenotypic signatures of immune selection in HIV-1 reservoir cells
Abstract Human immunodeficiency virus 1 (HIV-1) reservoir cells persist lifelong despite
antiretroviral treatment, but may be vulnerable to host immune responses that could be …
antiretroviral treatment, but may be vulnerable to host immune responses that could be …
Human circulating and tissue-resident memory CD8+ T cells
Our current knowledge of human memory CD8+ T cells is derived largely from studies of the
intravascular space. However, emerging data are starting to challenge some of the dogmas …
intravascular space. However, emerging data are starting to challenge some of the dogmas …
[HTML][HTML] CAR T cells for infection, autoimmunity and allotransplantation
Chimeric antigen receptors (CARs) have shown remarkable ability to re-direct T cells to
target CD19-expressing tumours, resulting in remission rates of up to 90% in individuals with …
target CD19-expressing tumours, resulting in remission rates of up to 90% in individuals with …
[HTML][HTML] The Evolving Role of CD8+CD28− Immunosenescent T Cells in Cancer Immunology
WX Huff, JH Kwon, M Henriquez, K Fetcko… - International journal of …, 2019 - mdpi.com
Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune
response to cancer. Thus, induction of their activity is the ultimate aim of all …
response to cancer. Thus, induction of their activity is the ultimate aim of all …
[HTML][HTML] Lung innervation in the eye of a cytokine storm: neuroimmune interactions and COVID-19
F De Virgiliis, S Di Giovanni - Nature Reviews Neurology, 2020 - nature.com
COVID-19 is an infectious disease caused by the coronavirus SARS-CoV-2, which was first
reported in Wuhan, China, in December 2019 and has caused a global pandemic. Acute …
reported in Wuhan, China, in December 2019 and has caused a global pandemic. Acute …
Cytolytic CD8+ T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes
DR Collins, J Hitschfel, JM Urbach… - Science …, 2023 - science.org
Follicular CD8+ T cells (fCD8) mediate surveillance in lymph node (LN) germinal centers
against lymphotropic infections and cancers, but the precise mechanisms by which these …
against lymphotropic infections and cancers, but the precise mechanisms by which these …
Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue
Current paradigms of CD8+ T cell–mediated protection in HIV infection center almost
exclusively on studies of peripheral blood, which is thought to provide a window into …
exclusively on studies of peripheral blood, which is thought to provide a window into …
[HTML][HTML] The identity of human tissue-emigrant CD8+ T cells
Lymphocyte migration is essential for adaptive immune surveillance. However, our current
understanding of this process is rudimentary, because most human studies have been …
understanding of this process is rudimentary, because most human studies have been …