Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes
DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …
Mechanism and regulation of meiotic recombination initiation
I Lam, S Keeney - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
Meiotic recombination involves the formation and repair of programmed DNA double-strand
breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent …
breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent …
[HTML][HTML] Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions
M Rotheneder, K Stakyte, E van de Logt, JD Bartho… - Molecular cell, 2023 - cell.com
The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …
[HTML][HTML] A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation
The nonrandom distribution of meiotic recombination influences patterns of inheritance and
genome evolution, but chromosomal features governing this distribution are poorly …
genome evolution, but chromosomal features governing this distribution are poorly …
Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins
DNA repair is an essential process for preserving genome integrity in all organisms. In
eukaryotes, recombinational repair is choreographed by multiprotein complexes that are …
eukaryotes, recombinational repair is choreographed by multiprotein complexes that are …
Recombination proteins in yeast
BO Krogh, LS Symington - Annu. Rev. Genet., 2004 - annualreviews.org
▪ Abstract The process of homologous recombination promotes error-free repair of double-
strand breaks and is essential for meiosis. Central to the process of homologous …
strand breaks and is essential for meiosis. Central to the process of homologous …
Initiation of meiotic recombination: how and where? Conservation and specificities among eukaryotes
B de Massy - Annual review of genetics, 2013 - annualreviews.org
Meiotic recombination is essential for fertility in most sexually reproducing species. This
process also creates new combinations of alleles and has important consequences for …
process also creates new combinations of alleles and has important consequences for …
High-resolution mapping of meiotic crossovers and non-crossovers in yeast
Meiotic recombination has a central role in the evolution of sexually reproducing organisms.
The two recombination outcomes, crossover and non-crossover, increase genetic diversity …
The two recombination outcomes, crossover and non-crossover, increase genetic diversity …
DNA end resection: many nucleases make light work
EP Mimitou, LS Symington - DNA repair, 2009 - Elsevier
Double-strand breaks (DSBs) are deleterious DNA lesions and if left unrepaired result in
severe genomic instability. Cells use two main pathways to repair DSBs: homologous …
severe genomic instability. Cells use two main pathways to repair DSBs: homologous …
Spo11 and the formation of DNA double-strand breaks in meiosis
S Keeney - Recombination and meiosis: crossing-over and …, 2007 - Springer
Meiotic recombination is carried out through a specialized pathway for the formation and
repair of DNA double-strand breaks made by the Spo11 protein, a relative of archaeal …
repair of DNA double-strand breaks made by the Spo11 protein, a relative of archaeal …