The diagnostic and prognostic potential of the vast quantity of publicly-available microarray
data has driven the development of methods for integrating the data from different …

Activated caspases are a hallmark of apoptosis induced by the intrinsic pathway, but they
are dispensable for cell death and the apoptotic clearance of cells in vivo. This has led to the …

Protocadherins (Pcdhs) are a group of cell-cell adhesion molecules that are highly
expressed in the nervous system and have a major function in dendrite development and …

Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α
(ERα) function and breast cancer prognosis. Here we show that PR is not merely an ERα …

The identification of genes and regulatory elements underlying the associations discovered
by GWAS is essential to understanding the aetiology of complex traits (including diseases) …

Germ-line genetic control of gene expression occurs via expression quantitative trait loci
(eQTLs). We present a large, exon-specific eQTL data set covering ten human brain regions …

The genetic background of childhood body mass index (BMI), and the extent to which the
well-known associations of childhood BMI with adult diseases are explained by shared …

Sjögren's syndrome is a common autoimmune disease (affecting∼ 0.7% of European
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we …

The contribution of repetitive elements to quantitative human traits is largely unknown. Here
we report a genome-wide survey of the contribution of short tandem repeats (STRs), which …

Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad
range of clinical manifestations, differential pathological signatures, and genetic variability …