CRISPR/Cas9 therapeutics: progress and prospects
T Li, Y Yang, H Qi, W Cui, L Zhang, X Fu, X He… - … and Targeted Therapy, 2023 - nature.com
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …
[HTML][HTML] Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing
S Zhang, J Shen, D Li, Y Cheng - Theranostics, 2021 - ncbi.nlm.nih.gov
CRISPR/Cas9 genome editing has gained rapidly increasing attentions in recent years,
however, the translation of this biotechnology into therapy has been hindered by efficient …
however, the translation of this biotechnology into therapy has been hindered by efficient …
Drosophila suzukii (Diptera: Drosophilidae): A Decade of Research Towards a Sustainable Integrated Pest Management Program
G Tait, S Mermer, D Stockton, J Lee… - Journal of Economic …, 2021 - academic.oup.com
Abstract Drosophila suzukii (Matsumura)(Diptera: Drosophilidae) also known as spotted-
wing drosophila (SWD), is a pest native to Southeast Asia. In the last few decades, the pest …
wing drosophila (SWD), is a pest native to Southeast Asia. In the last few decades, the pest …
CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo
MA Moreno-Mateos, CE Vejnar, JD Beaudoin… - Nature …, 2015 - nature.com
CRISPR-Cas9 technology provides a powerful system for genome engineering. However,
variable activity across different single guide RNAs (sgRNAs) remains a significant …
variable activity across different single guide RNAs (sgRNAs) remains a significant …
Highly Specific and Efficient CRISPR/Cas9-Catalyzed Homology-Directed Repair in Drosophila
SJ Gratz, FP Ukken, CD Rubinstein, G Thiede… - Genetics, 2014 - academic.oup.com
We and others recently demonstrated that the readily programmable CRISPR/Cas9 system
can be used to edit the Drosophila genome. However, most applications to date have relied …
can be used to edit the Drosophila genome. However, most applications to date have relied …
Genetics on the Fly: A Primer on the Drosophila Model System
KG Hales, CA Korey, AM Larracuente, DM Roberts - Genetics, 2015 - academic.oup.com
Fruit flies of the genus Drosophila have been an attractive and effective genetic model
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49883295&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49883295&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
sgRNAcas9: a software package for designing CRISPR sgRNA and evaluating potential off-target cleavage sites
S Xie, B Shen, C Zhang, X Huang, Y Zhang - PloS one, 2014 - journals.plos.org
Although the CRISPR/Cas9/sgRNA system efficiently cleaves intracellular DNA at desired
target sites, major concerns remain on potential “off-target” cleavage that may occur …
target sites, major concerns remain on potential “off-target” cleavage that may occur …
Nuclear domain 'knock-in'screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing
J Pinder, J Salsman, G Dellaire - Nucleic acids research, 2015 - academic.oup.com
CRISPR is a genome-editing platform that makes use of the bacterially-derived
endonuclease Cas9 to introduce DNA double-strand breaks at precise locations in the …
endonuclease Cas9 to introduce DNA double-strand breaks at precise locations in the …
[PDF][PDF] Characterization of Genomic Deletion Efficiency Mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 Nuclease System in …
MC Canver, DE Bauer, A Dass, YY Yien… - Journal of Biological …, 2014 - ASBMB
The clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated
(Cas) 9 nuclease system has provided a powerful tool for genome engineering. Double …
(Cas) 9 nuclease system has provided a powerful tool for genome engineering. Double …