Several different receptor proteins have been identified that bind monomeric, oligomeric, or
fibrillar forms of amyloid-β (Aβ)." Good" receptors internalize Aβ or promote its transcytosis …

The time and cost of developing new drugs have led many groups to limit their search for
therapeutics to compounds that have previously been approved for human use. Many …

The initial report that cellular prion protein (PrP C) mediates toxicity of amyloid-β species
linked to Alzheimer's disease was initially treated with scepticism, but growing evidence …

The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of
β-amyloid. Their interaction is mandatory for neurotoxic effects of β-amyloid oligomers. In …

Specific protein misfolding and aggregation are mechanisms underlying various
neurodegenerative diseases such as prion disease and Alzheimer's disease (AD). The …

The cellular prion protein (PrP C) is a key neuronal receptor for β-amyloid oligomers (AβO),
mediating their neurotoxicity, which contributes to the neurodegeneration in Alzheimer's …

Prion diseases are associated with the conversion of the cellular prion protein (PrPC), a
glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded …

Disrupted sleep is a major feature of Alzheimer's disease (AD), often arising years before
symptoms of cognitive decline. Prolonged wakefulness exacerbates the production of …

Despite the constant progress in the understanding of the etiopathogenesis of Alzheimer's
disease (AD) over the last 50 years, just four long-standing drugs are currently used for AD …

The increase of bacterial strains resistant to most of the available antibiotics shows a need to
explore novel antibacterial targets to discover antimicrobial drugs. Bifunctional bacterial FAD …