Role of insulin in health and disease: an update

MS Rahman, KS Hossain, S Das, S Kundu… - International journal of …, 2021 - mdpi.com
Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the
pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose …

The use of zebrafish (Danio rerio) as biomedical models

T Teame, Z Zhang, C Ran, H Zhang, Y Yang… - Animal …, 2019 - academic.oup.com
Implications Because of its fully sequenced genome, easy genetic manipulation, high
fecundity, external fertilization and rapid development, and nearly transparent embryo …

Effects of replacement of dietary fishmeal by cottonseed protein concentrate on growth performance, liver health, and intestinal histology of largemouth bass …

Y Liu, Q Lu, L Xi, Y Gong, J Su, D Han, Z Zhang… - Frontiers in …, 2021 - frontiersin.org
An 8-week feeding trial was conducted to explore the effects of replacement of dietary
fishmeal by cottonseed protein concentrate (CPC) on growth performance, liver health, and …

Multi- and Transgenerational Effects of Developmental Exposure to Environmental Levels of PFAS and PFAS Mixture in Zebrafish (Danio rerio)

A Haimbaugh, CC Wu, C Akemann, DN Meyer… - Toxics, 2022 - mdpi.com
Per-and polyfluoroalkyl substances (PFASs) are ubiquitous in the environment and are tied
to myriad health effects. Despite the phasing out of the manufacturing of two types of PFASs …

[HTML][HTML] Mitochondrial fatty acid β-oxidation inhibition promotes glucose utilization and protein deposition through energy homeostasis remodeling in fish

LY Li, JM Li, LJ Ning, DL Lu, Y Luo, Q Ma… - The Journal of …, 2020 - Elsevier
Background: Fish cannot use carbohydrate efficiently and instead utilize protein for energy
supply, thus limiting dietary protein storage. Protein deposition is dependent on protein …

Zebrafish facilitate non‐alcoholic fatty liver disease research: Tools, models and applications

C Chang, H Li, R Zhang - Liver International, 2023 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) has become an increasingly epidemic metabolic
disease worldwide. NAFLD can gradually deteriorate from simple liver steatosis …

Characterization of Sexual Trait Development in cyp17a1-Deficient Zebrafish

G Zhai, T Shu, Y Xia, Y Lu, G Shang, X Jin, J He… - …, 2018 - academic.oup.com
Abstract Cytochrome P450 (Cyp) 17A1 has both 17 α-hydroxylase and 17, 20-lyase
activities, which are involved in the steroidogenic pathway that produces androgens and …

Metabolic impact of frailty changes diabetes trajectory

AJ Sinclair, AH Abdelhafiz - Metabolites, 2023 - mdpi.com
Diabetes mellitus prevalence increases with increasing age. In older people with diabetes,
frailty is a newly emerging and significant complication. Frailty induces body composition …

Study on Carbohydrate Metabolism in Adult Zebrafish (Danio rerio)

L Xi, Q Lu, Y Liu, Y Gong, H Liu, J Jin… - Aquaculture …, 2023 - Wiley Online Library
Excessive carbohydrate intake leads to metabolic disorders in fish. However, few literatures
have reported the appropriate carbohydrate level for zebrafish, and the metabolic response …

Which Hyperglycemic Model of Zebrafish (Danio rerio) Suites My Type 2 Diabetes Mellitus Research? A Scoring System for Available Methods

A Salehpour, M Rezaei, A Khoradmehr… - Frontiers in cell and …, 2021 - frontiersin.org
Despite extensive studies on type 2 diabetes mellitus (T2DM), there is no definitive cure,
drug, or prevention. Therefore, for developing new therapeutics, proper study models of …