Bioactivity assessment and toxicity of crocin: a comprehensive review

SH Alavizadeh, H Hosseinzadeh - Food and chemical toxicology, 2014 - Elsevier
Since ancient times, saffron, the dried stigma of the plant Crocus sativus L. has been
extensively used as a spice and food colorant; in folk medicine it has been reputed to be …

Saffron in the treatment of depression, anxiety and other mental disorders: Current evidence and potential mechanisms of action

M Shafiee, S Arekhi, A Omranzadeh… - Journal of Affective …, 2018 - Elsevier
Background Depression and anxiety are two common mental health problems with high
economic and social costs. Currently, a number of treatments are available for patients with …

Main chemical compounds and pharmacological activities of stigmas and tepals of 'red gold'; saffron

T Shahi, E Assadpour, SM Jafari - Trends in Food Science & Technology, 2016 - Elsevier
Background Crocus sativus L.(saffron) belongs to Iridaceae family which is commonly
cultivated in Asia, Europe and America. The commercial product and use of saffron comes …

Antiinflammatory, Antioxidant, and Immunomodulatory Effects of Crocus sativus L. and its Main Constituents

MH Boskabady, T Farkhondeh - Phytotherapy Research, 2016 - Wiley Online Library
Crocus sativus L.(C. sativus), commonly known as saffron, is used as a food additive,
preservative, and medicinal herb. Traditionally, it has been used as an alternative treatment …

A comprehensive review on anticancer mechanisms of the main carotenoid of saffron, crocin

R Hoshyar, H Mollaei - Journal of Pharmacy and Pharmacology, 2017 - academic.oup.com
Objectives Crocin is derived from dried stigmas of Crocus sativus L.(saffron). It has long
been used to prevent and treat various diseases. Although crocin is suggested as one of the …

Improving the cancer prevention/treatment role of carotenoids through various nano-delivery systems

M Zare, Z Norouzi Roshan, E Assadpour… - Critical Reviews in …, 2021 - Taylor & Francis
One of the emerging and recent strategies to combat cancer is application of natural
bioactive compounds and phytochemicals. Carotenoids including lycopene, β-carotene …

Crocus sativus a natural food coloring and flavoring has potent anti-tumor properties

Z Khorasanchi, M Shafiee, F Kermanshahi, M Khazaei… - Phytomedicine, 2018 - Elsevier
Background Saffron, the dried stigmas of Crocus sativus L., is a highly valued agricultural
product that is used mainly as a food coloring and flavoring agent. Three main secondary …

[HTML][HTML] Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms

A Mokhtari-Zaer, MR Khazdair… - Avicenna journal of …, 2015 - ncbi.nlm.nih.gov
Abstract Saffron, Crocus sativus L.(C. sativus) is rich in carotenoids and used in traditional
medicine for treatment of various conditions such as coughs, stomach disorders …

Comparison of the effect of crocin and crocetin, two major compounds extracted from saffron, on osteogenic differentiation of mesenchymal stem cells

F Kalalinia, H Ghasim, SA Farzad, E Pishavar… - Life sciences, 2018 - Elsevier
Abstract Background Mesenchymal stem cells (MSCs) can be considered as an effective
tool for bone regeneration. It is variable to find new agents with low cytotoxicity and high …

Therapeutic potency of crocin in the treatment of inflammatory diseases: Current status and perspective

M Pashirzad, M Shafiee, A Avan… - Journal of Cellular …, 2019 - Wiley Online Library
Crocin is the major component of saffron, which is used in phytomedicine for the treatment of
several diseases including diabetes, fatty liver, depression, menstruation disorders, and, of …