Pediatric tuberculosis: the impact of “omics” on diagnostics development
S Jakhar, AA Bitzer, LR Stromberg… - International journal of …, 2020 - mdpi.com
Tuberculosis (TB) is a major public health concern for all ages. However, the disease
presents a larger challenge in pediatric populations, partially owing to the lack of reliable …
presents a larger challenge in pediatric populations, partially owing to the lack of reliable …
Systematic review of NMR-based metabolomics practices in human disease research
Nuclear magnetic resonance (NMR) spectroscopy is one of the principal analytical
techniques for metabolomics. It has the advantages of minimal sample preparation and high …
techniques for metabolomics. It has the advantages of minimal sample preparation and high …
Comprehensive lipid and lipid-related gene investigations of host immune responses to characterize metabolism-centric biomarkers for pulmonary tuberculosis
Despite remarkable success in the prevention and treatment of tuberculosis (TB), it remains
one of the most devastating infectious diseases worldwide. Management of TB requires an …
one of the most devastating infectious diseases worldwide. Management of TB requires an …
Integration of metabolomics and transcriptomics reveals novel biomarkers in the blood for tuberculosis diagnosis in children
NK Dutta, JA Tornheim, KF Fukutani, M Paradkar… - Scientific reports, 2020 - nature.com
Pediatric tuberculosis (TB) remains a major global health problem. Improved pediatric
diagnostics using readily available biosources are urgently needed. We used liquid …
diagnostics using readily available biosources are urgently needed. We used liquid …
Pediatric tuberculosis diagnostics: present and future
FW Basile, P Nabeta, M Ruhwald… - Journal of the Pediatric …, 2022 - academic.oup.com
The current diagnostic abilities for the detection of pediatric tuberculosis are suboptimal.
Multiple factors contribute to the under-diagnosis of intrathoracic tuberculosis in children …
Multiple factors contribute to the under-diagnosis of intrathoracic tuberculosis in children …
Host lipidome and tuberculosis treatment failure
Introduction Host lipids play important roles in tuberculosis (TB) pathogenesis. Whether host
lipids at TB treatment initiation (baseline) affect subsequent treatment outcomes has not …
lipids at TB treatment initiation (baseline) affect subsequent treatment outcomes has not …
Pathway‐based integration of multi‐omics data reveals lipidomics alterations validated in an Alzheimer's disease mouse model and risk loci carriers
ME Garcia‐Segura, BR Durainayagam… - Journal of …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder. Despite
increasing evidence of the importance of metabolic dysregulation in AD, the underlying …
increasing evidence of the importance of metabolic dysregulation in AD, the underlying …
Diagnostic potential of combining plasma biomarkers of tissue damage and inflammation in pediatric TB
A López-Suárez, M Santos-Sebastián… - Journal of Microbiology …, 2024 - Elsevier
Introduction Immune-based diagnostic tests for tuberculosis (TB) have suboptimal sensitivity
in children and cannot differentiate between latent infection (LTBI) and active disease. This …
in children and cannot differentiate between latent infection (LTBI) and active disease. This …
Untargeted Metabolomics of Feces Reveals Diagnostic and Prognostic Biomarkers for Active Tuberculosis and Latent Tuberculosis Infection: Potential Application for …
D Luo, BY Yang, K Qin, CY Shi, NS Wei… - Infection and Drug …, 2023 - Taylor & Francis
Purpose Distinguishing latent tuberculosis infection (LTBI) from active tuberculosis (ATB) is
important to control the prevalence of tuberculosis; however, there is currently no effective …
important to control the prevalence of tuberculosis; however, there is currently no effective …
Small molecule bio‐signature in childhood intra‐thoracic tuberculosis identified by metabolomics
The diagnosis of pediatric tuberculosis (TB) remains a major challenge, hence the
evaluation of new tools for improved diagnostics is urgently required. We investigated the …
evaluation of new tools for improved diagnostics is urgently required. We investigated the …