Pediatric tuberculosis: the impact of “omics” on diagnostics development

S Jakhar, AA Bitzer, LR Stromberg… - International journal of …, 2020 - mdpi.com
Tuberculosis (TB) is a major public health concern for all ages. However, the disease
presents a larger challenge in pediatric populations, partially owing to the lack of reliable …

Systematic review of NMR-based metabolomics practices in human disease research

K Huang, N Thomas, PR Gooley, CW Armstrong - Metabolites, 2022 - mdpi.com
Nuclear magnetic resonance (NMR) spectroscopy is one of the principal analytical
techniques for metabolomics. It has the advantages of minimal sample preparation and high …

Comprehensive lipid and lipid-related gene investigations of host immune responses to characterize metabolism-centric biomarkers for pulmonary tuberculosis

NP Long, NK Anh, NTH Yen, NK Phat, S Park… - Scientific Reports, 2022 - nature.com
Despite remarkable success in the prevention and treatment of tuberculosis (TB), it remains
one of the most devastating infectious diseases worldwide. Management of TB requires an …

Integration of metabolomics and transcriptomics reveals novel biomarkers in the blood for tuberculosis diagnosis in children

NK Dutta, JA Tornheim, KF Fukutani, M Paradkar… - Scientific reports, 2020 - nature.com
Pediatric tuberculosis (TB) remains a major global health problem. Improved pediatric
diagnostics using readily available biosources are urgently needed. We used liquid …

Pediatric tuberculosis diagnostics: present and future

FW Basile, P Nabeta, M Ruhwald… - Journal of the Pediatric …, 2022 - academic.oup.com
The current diagnostic abilities for the detection of pediatric tuberculosis are suboptimal.
Multiple factors contribute to the under-diagnosis of intrathoracic tuberculosis in children …

Host lipidome and tuberculosis treatment failure

R Shivakoti, JW Newman, LE Hanna… - European …, 2022 - Eur Respiratory Soc
Introduction Host lipids play important roles in tuberculosis (TB) pathogenesis. Whether host
lipids at TB treatment initiation (baseline) affect subsequent treatment outcomes has not …

Pathway‐based integration of multi‐omics data reveals lipidomics alterations validated in an Alzheimer's disease mouse model and risk loci carriers

ME Garcia‐Segura, BR Durainayagam… - Journal of …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder. Despite
increasing evidence of the importance of metabolic dysregulation in AD, the underlying …

Diagnostic potential of combining plasma biomarkers of tissue damage and inflammation in pediatric TB

A López-Suárez, M Santos-Sebastián… - Journal of Microbiology …, 2024 - Elsevier
Introduction Immune-based diagnostic tests for tuberculosis (TB) have suboptimal sensitivity
in children and cannot differentiate between latent infection (LTBI) and active disease. This …

Untargeted Metabolomics of Feces Reveals Diagnostic and Prognostic Biomarkers for Active Tuberculosis and Latent Tuberculosis Infection: Potential Application for …

D Luo, BY Yang, K Qin, CY Shi, NS Wei… - Infection and Drug …, 2023 - Taylor & Francis
Purpose Distinguishing latent tuberculosis infection (LTBI) from active tuberculosis (ATB) is
important to control the prevalence of tuberculosis; however, there is currently no effective …

Small molecule bio‐signature in childhood intra‐thoracic tuberculosis identified by metabolomics

N Sharma, D Upadhyay, H Gautam… - NMR in …, 2023 - Wiley Online Library
The diagnosis of pediatric tuberculosis (TB) remains a major challenge, hence the
evaluation of new tools for improved diagnostics is urgently required. We investigated the …