A simple method for developing lysine targeted covalent protein reagents

R Gabizon, B Tivon, RN Reddi… - Nature …, 2023 - nature.com
Peptide-based covalent probes can target shallow protein surfaces not typically addressable
using small molecules, yet there is a need for versatile approaches to convert native peptide …

Harnessing Aromatic‐Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification

Z Yu, DF Kreitler, YTT Chiu, R Xu… - Angewandte …, 2023 - Wiley Online Library
Peptide engineering efforts have delivered drugs for diverse human diseases. Side chain
alteration is among the most common approaches to designing new peptides for specific …