Microbial cells operate under governing constraints that limit their range of possible
functions. With the availability of annotated genome sequences, it has become possible to …

Understanding the dynamics of redox elements in biologic systems remains a major
challenge for redox signaling and oxidative stress research. Central redox elements include …

A new form of metabolic flux analysis (MFA) called thermodynamics-based metabolic flux
analysis (TMFA) is introduced with the capability of generating thermodynamically feasible …

We build a rigorous nonequilibrium thermodynamic description for open chemical reaction
networks of elementary reactions. Their dynamics is described by deterministic rate …

Metabolic pathways may seem arbitrary and unnecessarily complex. In many cases, a
chemist might devise a simpler route for the biochemical transformation, so why has nature …

While the reductive pentose phosphate cycle is responsible for the fixation of most of the
carbon in the biosphere, it has several natural substitutes. In fact, due to the characterization …

Studying cell metabolism serves a plethora of objectives such as the enhancement of
bioprocess performance, and advancement in the understanding of cell biology, of drug …

The title of this book already says something about its contents and historical origin, but
since it is meant in a rigorous mathematical context, a few words of explanation may be …

The constraint-based reconstruction and analysis (COBRA) framework has been widely
used to study steady-state flux solutions in genome-scale metabolic networks. One …

Elementary mode analysis is a useful metabolic pathway analysis tool to identify the
structure of a metabolic network that links the cellular phenotype to the corresponding …