T cell antigen receptor recognition of antigen-presenting molecules
The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
[HTML][HTML] TCR recognition of peptide–MHC-I: Rule makers and breakers
T cells are a critical part of the adaptive immune system that are able to distinguish between
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …
[HTML][HTML] Deconstructing the peptide-MHC specificity of T cell recognition
In order to survey a universe of major histocompatibility complex (MHC)-presented peptide
antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors …
antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors …
Understanding the drivers of MHC restriction of T cell receptors
T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
[HTML][HTML] Immune self-reactivity triggered by drug-modified HLA-peptide repertoire
Human leukocyte antigens (HLAs) are highly polymorphic proteins that initiate immunity by
presenting pathogen-derived peptides to T cells. HLA polymorphisms mostly map to the …
presenting pathogen-derived peptides to T cells. HLA polymorphisms mostly map to the …
Recognition of CD1d-restricted antigens by natural killer T cells
Natural killer T (NKT) cells are innate-like T cells that rapidly produce a variety of cytokines
following T cell receptor (TCR) activation and can shape the immune response in many …
following T cell receptor (TCR) activation and can shape the immune response in many …
[HTML][HTML] A single autoimmune T cell receptor recognizes more than a million different peptides
L Wooldridge, J Ekeruche-Makinde… - Journal of Biological …, 2012 - ASBMB
The T cell receptor (TCR) orchestrates immune responses by binding to foreign peptides
presented at the cell surface in the context of major histocompatibility complex (MHC) …
presented at the cell surface in the context of major histocompatibility complex (MHC) …
Evolving models of the immunopathogenesis of T cell–mediated drug allergy: The role of host, pathogens, and drug response
Immune-mediated (IM) adverse drug reactions (ADRs) are an underrecognized source of
preventable morbidity, mortality, and cost. Increasingly, genetic variation in the HLA loci is …
preventable morbidity, mortality, and cost. Increasingly, genetic variation in the HLA loci is …
The importance of non-HLA antibodies in transplantation
Q Zhang, EF Reed - Nature Reviews Nephrology, 2016 - nature.com
The development of post-transplantation antibodies against non-HLA autoantigens is
associated with rejection and decreased long-term graft survival. Although our knowledge of …
associated with rejection and decreased long-term graft survival. Although our knowledge of …
[HTML][HTML] T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex
T cell receptor (TCR) engagement of peptide-major histocompatibility complex (pMHC) is
essential to adaptive immunity, but it is unknown whether TCR signaling responses are …
essential to adaptive immunity, but it is unknown whether TCR signaling responses are …