Diversity and dynamism in the cerebellum

CI De Zeeuw, SG Lisberger, JL Raymond - Nature neuroscience, 2021 - nature.com
The past several years have brought revelations and paradigm shifts in research on the
cerebellum. Historically viewed as a simple sensorimotor controller with homogeneous …

Electrical synapses and their functional interactions with chemical synapses

AE Pereda - Nature Reviews Neuroscience, 2014 - nature.com
Brain function relies on the ability of neurons to communicate with each other. Interneuronal
communication primarily takes place at synapses, where information from one neuron is …

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

BG Wilhelm, S Mandad, S Truckenbrodt, K Kröhnert… - Science, 2014 - science.org
Synaptic vesicle recycling has long served as a model for the general mechanisms of
cellular trafficking. We used an integrative approach, combining quantitative immunoblotting …

Re-evaluating circuit mechanisms underlying pattern separation

NA Cayco-Gajic, RA Silver - Neuron, 2019 - cell.com
When animals interact with complex environments, their neural circuits must separate
overlapping patterns of activity that represent sensory and motor information. Pattern …

The cerebellar cortex

C Hull, WG Regehr - Annual review of neuroscience, 2022 - annualreviews.org
The cerebellar cortex is an important system for relating neural circuits and learning. Its
promise reflects the longstanding idea that it contains simple, repeated circuit modules with …

The geometric structure of the brain fiber pathways

VJ Wedeen, DL Rosene, R Wang, G Dai, F Mortazavi… - Science, 2012 - science.org
The structure of the brain as a product of morphogenesis is difficult to reconcile with the
observed complexity of cerebral connectivity. We therefore analyzed relationships of …

NeuroMatic: an integrated open-source software toolkit for acquisition, analysis and simulation of electrophysiological data

JS Rothman, RA Silver - Frontiers in neuroinformatics, 2018 - frontiersin.org
Acquisition, analysis and simulation of electrophysiological properties of the nervous system
require multiple software packages. This makes it difficult to conserve experimental …

Physiology of the cerebellum

E D'Angelo - Handbook of clinical neurology, 2018 - Elsevier
The cerebellum is a central brain structure deeply integrated into major loops with the
cerebral cortex, brainstem, and spinal cord. The cerebellum shows a complex regional …

Beyond plasticity: the dynamic impact of electrical synapses on neural circuits

P Alcamí, AE Pereda - Nature Reviews Neuroscience, 2019 - nature.com
Electrical synapses are found in vertebrate and invertebrate nervous systems. The cellular
basis of these synapses is the gap junction, a group of intercellular channels that mediate …

Gap junctions desynchronize a neural circuit to stabilize insect flight

S Hürkey, N Niemeyer, JH Schleimer, S Ryglewski… - Nature, 2023 - nature.com
Insect asynchronous flight is one of the most prevalent forms of animal locomotion used by
more than 600,000 species. Despite profound insights into the motor patterns …