Oxidative stress is implicated in the pathogenesis and progression of Alzheimer's disease
(AD) and its earlier stage, amnestic mild cognitive impairment (aMCI). One source of …

Alzheimer's disease (AD) is the most common form of dementia in the elderly followed by
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …

Significance: Alzheimer disease (AD) is an age-related neurodegenerative disease. AD is
characterized by progressive cognitive impairment. One of the main histopathological …

Oxidative stress is involved in various and numerous pathological states including several
age-related neurodegenerative diseases. Peroxidation of the membrane lipid bilayer is one …

Neurodegenerative diseases are characterized by chronic microglial over-activation and
oxidative stress. It is now beginning to be recognized that reactive oxygen species (ROS) …

Mild cognitive impairment (MCI) is rapidly becoming one of the most common clinical
manifestations affecting the elderly. The pathologic and molecular substrate of people …

Iron has emerged as a significant cause of neurotoxicity in several neurodegenerative
conditions, including Alzheimer's disease (AD), Parkinson's disease (PD), sporadic …

Bilirubin is the end product of heme catabolism formed during a process that involves
oxidation-reduction reactions and conserves iron body stores. Unconjugated …

Reactive oxygen species (ROS) and signaling events are involved in the pathogenesis of
endothelial dysfunction and represent a major contribution to vascular regulation. Molecular …

Modulation of endogenous cellular defense mechanisms via the vitagene system represents
an innovative approach to therapeutic intervention in diseases causing chronic tissue …